Efficacy of Bifidobacterium breve and Lactobacillus casei oral supplementation on necrotizing enterocolitis in very-low-birth-weight preterm infants: a double-blind, randomized, controlled trial
Efficacy of Bifidobacterium breve and Lactobacillus casei oral supplementation on necrotizing enterocolitis in very-low-birth-weight preterm infants: a double-blind, randomized, controlled trial
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DOI：
10.3945/ajcn.2010.29799
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发表时间：
2011-01-01
影响因子：
7.1
通讯作者：
Lima, Marilia de Carvalho
中科院分区：
文献类型：
--
作者：
Braga, Taciana Duque;Pontes da Silva, Giselia Alves;Lima, Marilia de Carvalho
背景：益生菌因其对肠道运动功能、炎症反应调节和粘膜屏障功能的积极作用而被用于预防坏死性小肠结肠炎（NEC）。目的：目的是评估干酪乳杆菌和短双歧杆菌联合应用是否可以按照贝尔标准预防极低出生体重早产儿NEC期>= 2的发生。设计：本研究采用双盲、随机、对照的临床试验方法，对231名出生时体重750 ~ 1499 g的早产儿进行研究。干预组由119名婴儿组成，他们服用添加了益生菌（短芽孢杆菌和干酪乳杆菌）的母乳，对照组112名婴儿服用不含益生菌的母乳。主要预后指标为Bell修订标准所定义的NEC期>= 2。结果：4例NEC分期>= 2贝尔标准确诊病例仅出现在对照组。结论：口服补充短芽孢杆菌和干酪乳杆菌可减少NEC的发生（Bell分期>= 2）。人们认为肠道运动的改善可能促成了这一结果。该试验已在www.isrctin.org注册，注册号为67165178（国际标准随机对照试验）。[J]中华临床杂志，2011;33(3):81- 86。
Background: Probiotics are used for the prevention of necrotizing enterocolitis (NEC) because of their positive effects on intestinal motor function, modulation of inflammatory response, and mucosal barrier function.Objective: The objective was to assess whether the combined use of Lactobacillus casei and Bifidobacterium breve may prevent the occurrence of NEC stage >= 2 by the criteria of Bell in very-low-birth-weight preterm infants.Design: A double-blind, randomized, controlled clinical trial was conducted in 231 preterm infants weighing from 750 to 1499 g at birth. The intervention group was composed of 119 infants who received human milk with probiotic supplementation (B. breve and L. casei) and a control group of 112 infants who received human milk containing no probiotics. The primary outcome was the occurrence of NEC stage >= 2 as defined by Bell's modified criteria.Results: Four confirmed cases of NEC stage >= 2 by Bell's criteria occurred only in the control group.Conclusions: Oral supplementation of B. breve and L. casei reduced the occurrence of NEC (Bell's stage >= 2). It was considered that an improvement in intestinal motility might have contributed to this result. This trial was registered at www.isrctin.org as number 67165178 (International Standard Randomized Controlled Trial). Am J Clin Nutr 2011;93:81-6.