AGE-DIFFERENCES IN A CIRCADIAN INFLUENCE ON HIPPOCAMPAL LTP
AGE-DIFFERENCES IN A CIRCADIAN INFLUENCE ON HIPPOCAMPAL LTP
复制标题
DOI：
10.1016/0006-8993(83)91284-2
复制
发表时间：
1983-01-01
期刊：
影响因子：
2.9
通讯作者：
TEYLER, TJ
中科院分区：
文献类型：
--
作者：
HARRIS, KM;TEYLER, TJ
对大鼠海马长时程增强（LTP）的几个实验数据进行了昼夜节律影响的检查。结果表明，CA 1区和齿状区LTP的发生率和强度存在着相互的光暗差异，CA 1区锥体细胞在光时LTP的发生率较高，齿状区颗粒细胞在暗时LTP的发生率较高。对发育中动物的实验结果表明，在出生后第20天之前，昼夜节律对这两个区域的LTP的影响并不存在。所有这些实验都是从海马切片制备;重要的是要注意，昼夜节律对海马LTP的影响在体外环境中被保留，其中强直性海马外输入可能已被删除。
Data from several experiments on long-term potentiation (LTP) in the rat hippocampus were examined for circadian influence. Incidence and magnitude of LTP produced in both area CA1 and area dentata were analyzed, and a reciprocal light/dark difference was found in the 2 areas, with pyramidal cells of area CA1 showing more LTP during the light period and granule cells of area dentata showing more LTP during the dark period. Results from experiments on developing animals suggested that the circadian influence on LTP in either area was not present before postnatal day 20. All of these experiments were from hippocampal slice preparations; it is important to note that circadian influences on hippocampal LTP are preserved in the in vitro environment, where tonic extrahippocampal input has presumably been removed.