Variation in visual acuity within pigmented, and between pigmented and albino rat strains
Variation in visual acuity within pigmented, and between pigmented and albino rat strains
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DOI：
10.1016/s0166-4328(02)00126-2
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发表时间：
2002-11-15
影响因子：
2.7
通讯作者：
Whishaw, IQ
中科院分区：
文献类型：
--
作者：
Prusky, GT;Harker, KT;Whishaw, IQ
许多研究人员假设实验大鼠视力不佳，因此，他们不需要考虑由于紧张或经历而导致的大鼠视觉功能的差异。目前，尚不清楚家鼠驯化是否对实验大鼠品系的视觉功能产生了负面影响，品系白化病对大鼠视觉功能的影响是什么，或者实验大鼠的视觉功能是否存在与色素沉着无关的品系差异。为了解决这些问题，我们对三个品系的实验大鼠(Dark Agti，Fisher-挪威，Long-Evans)和三个白化品系(Fisher-344，Spraogue-Dawley，Wistar)的垂直光栅敏感度进行了心理生理测量，并与野鼠的敏感度进行了比较。Dark Agti、Long-Evans和野生菌株的栅阈值聚集在1.0个周期/度(c/d)左右，彼此之间没有显著差异。然而，Fisher-挪威大鼠的阈值明显较高，为1.5c/d。聚集在0.5c/d左右的Fisher-344、Spraogue-Dawley和Wistar品系的栅阈值显著低于着色品系。这些数据表明，实验大鼠的视觉功能存在显著的应变变异性。驯化Long-Evans和Dark Agti品系似乎没有影响视力，但在费舍尔-挪威鼠的情况下，选择性繁殖可能提高了它们的敏锐度。然而，与白化病相关的菌株选择似乎一直损害视力。因此，在选择涉及视觉的行为任务的大鼠模型时，或者在比较不同品系的大鼠的视觉行为测量时，应该考虑到视觉功能的品系差异。(C)2002 Elsevier Science B.V.保留所有权利。
Many researchers assume that laboratory rats have poor vision, and accordingly, that they need not consider differences in the visual function of rats as a consequence of strain or experience. Currently, it is not specifically known whether rat domestication has negatively affected the visual function of laboratory rat strains, what the effects of strain albinism are on rat visual function, or whether there are strain differences in the visual function of laboratory rats that are independent of pigmentation. In order to address these questions, we measured psychophysically the vertical grating acuity of three pigmented (Dark Agouti, Fisher-Norway, Long-Evans) and three albino (Fisher-344, Sprague-Dawley, Wistar) strains of laboratory rats, and compared their acuity with that of wild rats. The grating thresholds of Dark Agouti, Long-Evans and wild strains clustered around 1.0 cycle/degree (c/d) and did not significantly differ from one another. Fisher-Norway rats, however, had a significantly higher threshold of 1.5 c/d. The grating thresholds of Fisher-344, Sprague-Dawley, and Wistar strains, which were clustered around 0.5 c/d, were significantly lower than those of the pigmented strains. These data demonstrate that there is significant strain variability in the visual function of laboratory rats. Domestication of Long-Evans and Dark Agouti strains does not appear to have compromised visual acuity, but in the case of Fisher-Norway rats, selective breeding may have enhanced their acuity. Strain selection associated with albinism, however, appears to have consistently impaired visual acuity. Therefore, a consideration of strain differences in visual function should accompany the selection of a rat model for behavioral tasks that involve vision, or when comparing visuo-behavioral measurements across rat strains. (C) 2002 Elsevier Science B.V. All rights reserved.