EFFECTS OF SEX STEROID HORMONES UPON LONGEVITY IN RATS
EFFECTS OF SEX STEROID HORMONES UPON LONGEVITY IN RATS
复制标题
DOI：
10.1530/jrf.0.0140113
复制
发表时间：
1967-01-01
期刊：
影响因子：
--
通讯作者：
SPERLING, GA
中科院分区：
文献类型：
--
作者：
ASDELL, SA;DOORNENBAL, H;SPERLING, GA
将11组大鼠，每组50只，置于统一管理条件下，比较不同处理组大鼠的寿命。女性比男性寿命更长，而卵巢切除往往会缩短女性的寿命，而去势则会延长男性的寿命。去性腺大鼠植入苯甲酸雌二醇不能延长雌性的寿命，但有延长雄性寿命的趋势。去性腺大鼠植入丙酸睾丸酮后，两性的平均寿命都有缩短的趋势。未繁殖的雌性平均寿命高于已繁殖的雌性，但在5%的水平上差异不显著。对于实验室大鼠来说，较晚的初始繁殖似乎比第一次在正常年龄繁殖更有害。轻度繁殖对雄性的平均寿命影响很小或没有影响。这些结论只是试探性的。结果是一致的，但它们大多缺乏可接受的统计意义。统计学上最显著的结果是，暴露于自己或植入雌激素的大鼠的平均寿命比暴露于自身或植入睾丸素的大鼠更长。
Eleven groups of fifty rats each were kept under uniform conditions of management and their life-spans under different treatments were compared. Females lived longer than males, while ovariectomy tended to shorten the life-span of females and castration to lengthen that of males. Implantation of gonadectomized rats with oestradiol benzoate did not prolong the life-span of the females but it did tend to prolong that of males. Implantation of gonadectomized rats with testosterone propionate tended to shorten the average life-span of both sexes. Unbred females outlived bred ones, on the average, but the difference was not significant at the 5% level. Late initial breeding appeared to be more harmful than breeding for the first time at the usual age for laboratory rats. Light breeding had little or no effect upon the average longevity of males. These conclusions are tentative. The results are consistent but they mostly lack acceptable statistical significance. The most significant result statistically was that rats exposed to their own or implanted oestrogens had a longer average life -span than did those exposed to their own or to implanted testosterone.