Endometriosis among women exposed to polybrominated biphenyls
Endometriosis among women exposed to polybrominated biphenyls
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DOI：
10.1016/j.annepidem.2006.11.005
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发表时间：
2007-07-01
影响因子：
5.6
通讯作者：
Marcus, Michele
中科院分区：
文献类型：
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作者：
Hoffman, Caroline S.;Small, Chanley M.;Marcus, Michele
目得：我们于1973年在无意中暴露于多溴联苯（PBBs）和多氯联苯（PCBs）的妇女中研究了子宫内膜异位症与PBBs和PCBs暴露之间的关系。女性在1997年的访谈中自我报告子宫内膜异位症。我们构建了考克斯模型来估计子宫内膜异位症的相对发病率与多溴联苯和多氯联苯level.RESULTS：七十九943名妇女（9%）报告子宫内膜异位症。与多溴联苯低暴露（= 4 ppb）的妇女相比（FIR = 0.90; 95% CI，0.51-1.59），暴露没有增加子宫内膜异位症的发病率。与低PCB暴露水平相比，暴露于中等PCB（5-8 ppb）（HR = 1.67; 95% CI，0.91-3.10）和高PCB（>= 8 ppb）（HR = 1.68; 95% CI，0.95-2.98）水平的妇女子宫内膜异位症的发病率增加。
PURPOSE: We examined the association between endometriosis and exposure to polybrominated biphenyls (PBBs) and polychlorinated biphenyls (PCBs) among women inadvertently exposed to PBBs in 1973.METHODS: Serum PBBs and PCBs were measured in the late 1970s. Women self-reported endometriosis at interview in 1997. We constructed Cox models to estimate the relative incidence of endometriosis in relation to PBB and PCB levels.RESULTS: Seventy-nine of 943 women (9%) reported endometriosis. Compared with women with low PBB exposure (= 4 ppb) (FIR = 0.90; 95% Cl, 0.51-1.59) exposure did not have increased incidence of endometriosis. Increased incidence of endometriosis was suggested among women exposed to moderate PCB (5-8 ppb) (HR = 1.67; 95% Cl, 0.91-3.10) and high PCB (>= 8 ppb) (HR = 1.68; 95% Cl, 0.95-2.98) levels compared with low PCB exposure (