Prognostic value of tumor-infiltrating FOXP3+ regulatory T cells in patients with hepatocellular carcinoma
Prognostic value of tumor-infiltrating FOXP3+ regulatory T cells in patients with hepatocellular carcinoma
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DOI：
10.1016/j.ejso.2007.08.008
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发表时间：
2008-02-01
期刊：
影响因子：
3.8
通讯作者：
Mori, M.
中科院分区：
文献类型：
--
作者：
Sasaki, A.;Tanaka, F.;Mori, M.
目的：CD 4（+）CD 25（+）FOXP 3（+）T-reg在恶性肿瘤中聚集并负性调节抗肿瘤免疫。为了确定肿瘤浸润性调节性T细胞（T-reg）的预后价值，我们对164例接受根治性肝切除术的肝细胞癌（HCC）患者进行了回顾性研究。方法：我们调查了福尔马林固定的HCC标本中肿瘤浸润性FOXP 3（+）T-reg的数量。每种情况的FOXP 3（+）T-reg的数量计算为光学显微镜下每10个高倍视野（HPF）的阳性细胞总数。结果：FOXP 3（+）T-reg的平均值和中位数分别为29.0/10 HPF和14/10 HPF，FOXP 3（+）T-reg的数量与术前血清甲胎蛋白水平呈正相关。T-reg计数高的患者（>= 14，n = 84）的无病生存率显著低于T-reg计数低的患者（
Aims: CD4(+) CD25(+) forkhead box P3 (FOXP3)(+) T-reg accumulate in malignant tumors and negatively regulate anti-tumor immunity. To determine the prognostic value of tumor-infiltrating regulatory T cells (T-reg), we conducted a retrospective study on 164 patients with hepatocellular carcinoma (HCC) who underwent curative hepatic resection.Methods: We investigated the number of tumor-infiltrating FOXP3(+) T-reg in formalin-fixed HCC specimens. The number of FOXP3(+) T-reg for each case was calculated as the total number of positive cells per 10 high-power fields (HPF) on light microscopy. Long-term survival rate after resection according to the number of FOXP3(+) T-reg was accessed by univariate and multivariate analyses.Results: The mean and median numbers of tumor-infiltrating T-reg were 29.0 and 14 per 10 HPF for FOXP3(+) T-reg. The number of FOXP3(+) T-reg was positively correlated with preoperative serum alpha-fetoprotein levels. The disease-free survival rate was significantly lower in patients with high T-reg counts (>= 14, n = 84) than in those with low T-reg counts (