Randomized trial reveals that physical activity and energy expenditure are associated with weight and body composition after RYGB.
Randomized trial reveals that physical activity and energy expenditure are associated with weight and body composition after RYGB.
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DOI：
10.1002/oby.21864
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Goodpaster BH
中科院分区：
文献类型：
--
作者：
Carnero EA;Dubis GS;Hames KC;Jakicic JM;Houmard JA;Coen PM;Goodpaster BH
我们研究了Roux-en-Y胃分流术(RYGB)术后患者体力活动时间(PA)和能量消耗(EE)与体重和脂肪减少(FM)的关系。96名非糖尿病患者被纳入这项分析。RYGB后的患者随机接受两种治疗之一：为期6个月的运动训练计划(RYBG+EX)或生活方式教育课程(RYGB)。用双能X线骨密度仪和计算机断层扫描评估身体成分。我们用多感官装置对PA和EE的成分进行了定量。我们根据每天步数变化的四分位数，探索PA和EE与体重减轻和身体成分的剂量-反应关系。步数/天变化最大四分之一的患者减少了更多的脂肪(Fm)(第3=−19.5 kg和第4=−22.7 kg，P<；0.05)和腹部脂肪组织(−第4=−313 cm2，P<；0.05)；维持骨骼肌块(第3=3.1 cm2和−第4=−4.5 cm2，P<；0.05)，并有更大的静息代谢率下降。久坐EE减少、轻度EE增加和年龄是Δ体重和ΔFM的显著预测因子(R2=73.8%和R2=70.6%)。接受RYGB治疗的非糖尿病患者进行较高的PA量-但仍然适中-有更大的能量缺乏，减轻更多的体重和身体脂肪质量，同时保持更高的骨骼肌量。
We investigated the associations of both physical activity time (PA) and energy expenditure (EE) with weight and fat mass (FM) loss in patients following Roux-en-Y gastric bypass (RYGB) surgery. Ninety-six non-diabetic patients were included in this analysis. Post RYGB patients were randomized in one of two treatments: A 6-month exercise training program (RYBG+EX) or lifestyle educational classes (RYGB). Body composition was assessed by dual-energy X-ray absorptiometry and computed tomography. We quantified components of PA and EE by a multisensory device. We explored dose-response relationships of both PA and EE with weight loss and body composition according to quartiles of change in steps/day. Patients in the highest quartile of steps/day change lost more fat mass (FM) (3rd =−19.5kg and 4th=−22.7kg, P<0.05) and abdominal adipose tissue (− 4th=−313cm2, P<0.05);, maintained skeletal muscle mass (3rd = 3.1cm2 and −4th=−4.5cm2, P<0.05) and had greater reductions in resting metabolic rate. Decreases in sedentary EE, increases in Light EE and age were significant predictors of both Δweight and ΔFM (R2 =73.8% and R2 =70.6%, respectively). Non-diabetic patients who perform higher - yet still modest - amounts of PA following RYGB have greater energy deficits, lose more weight and body fat mass, while maintaining higher skeletal muscle mass.
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DOI：
10.1038/oby.2010.88
发表时间：
2010-12
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Bond DS;Jakicic JM;Unick JL;Vithiananthan S;Pohl D;Roye GD;Ryder BA;Sax HC;Wing RR
通讯作者：
Wing RR
影响因子：
5.8
作者：
Johannsen, Darcy L.;Knuth, Nicolas D.;Hall, Kevin D.
通讯作者：
Hall, Kevin D.
影响因子：
15.9
作者：
Coen, Paul M.;Tanner, Charles J.;Goodpaster, Bret H.
通讯作者：
Goodpaster, Bret H.
影响因子：
7.1
作者：
KEMPEN, KPG;SARIS, WHM;WESTERTERP, KR
通讯作者：
WESTERTERP, KR
影响因子：
3.1
作者：
Reece, Joel D.;Barry, Vaughn;Caputo, Jennifer
通讯作者：
Caputo, Jennifer