Is human fecundity declining?
Is human fecundity declining?
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DOI：
10.1111/j.1365-2605.2005.00573.x
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发表时间：
2006-02-01
影响因子：
--
通讯作者：
Toppari, J
中科院分区：
文献类型：
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作者：
Skakkebæk, NE;Jorgensen, N;Toppari, J
在许多工业化国家，生育率下降的趋势现在是如此引人注目，值得更多的科学关注。虽然社会和行为因素无疑在这些趋势中起着重要作用，但得出这些趋势可以单独归因于社会和行为变化的结论似乎为时过早，而且没有根据可靠的信息。有证据表明，生活方式的改变和环境暴露（例如内分泌干扰物）的增加是发生配偶生殖健康问题（包括睾丸癌、睾丸隐睾和精液质量差）趋势的原因。这些生物因素也可能导致生育率极低。然而，必要的研究是复杂的，需要人口统计学家、流行病学家、临床医生、生物学家、野生动物研究人员、遗传学家和分子生物学家之间非传统的合作。如果没有政府和资助机构的大力支持，这项研究工作几乎不可能开展，这些机构使资助新的科学家研究网络中的合作项目成为可能。
The decreasing trends in fertility rates in many industrialized countries are now so dramatic that they deserve much more scientific attention. Although social and behavioural factors undoubtedly play a major role for these trends, it seems premature, and not based on solid information, to conclude that these trends can be ascribed to social and behavioural changes alone. There is evidence to suspect that changing lifestyle and increasing environmental exposures, e.g. to endocrine disrupters, are behind the trends in occurrence of mate reproductive health problems, including testis cancer, undescended testis and poor semen quality. These biological factors may also contribute to the extremely low fertility rates. However, the necessary research is complex and requires non-traditional collaboration between demographers, epidemiologists, clinicians, biologists, wild life researchers, geneticists and molecular biologists. This research effort can hardly be carried out without major support from governments and granting agencies making it possible to fund collaborative projects within novel research networks of scientists.