NONOXIDATIVE GLUCOSE CONSUMPTION DURING FOCAL PHYSIOLOGIC NEURAL ACTIVITY
NONOXIDATIVE GLUCOSE CONSUMPTION DURING FOCAL PHYSIOLOGIC NEURAL ACTIVITY
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DOI：
10.1126/science.3260686
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发表时间：
1988-07-22
期刊：
影响因子：
56.9
通讯作者：
DENCE, C
中科院分区：
文献类型：
--
作者：
FOX, PT;RAICHLE, ME;DENCE, C
用正电子发射断层扫描仪测量了人类的脑葡萄糖摄取、氧代谢和血流量，得到了静息状态下氧与葡萄糖消耗的摩尔比为4.1：1。然而，生理神经活动增加葡萄糖摄取和血流量（分别为51%和50%）比氧消耗（5%）多得多，并产生0.4：1的摩尔比增加。神经活动的瞬时增加导致组织摄取的葡萄糖超过氧化代谢消耗的葡萄糖，急性消耗的能量比以前认为的少得多，并调节局部血流用于氧化代谢以外的目的。
Brain glucose uptake, oxygen metabolism, and blood flow in humans were measured with positron emission tomography, and a resting-state molar ratio of oxygen to glucose consumption of 4.1:1 was obtained. Physiological neural activity, however, increased glucose uptake and blood flow much more (51 and 50 percent, respectively) than oxygen consumption (5 percent) and produced a molar ratio for the increases of 0.4:1. Transient increases in neural activity cause a tissue uptake of glucose in excess of that consumed by oxidative metabolism, acutely consume much less energy than previously believed, and regulate local blood flow for purposes other than oxidative metabolism.