Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer.
Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer.
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长链非编码 RNA 在癌症中的作用、功能和机制。
DOI：
10.1016/j.gpb.2015.09.006
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Fullwood MJ
中科院分区：
文献类型：
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作者：
Fang Y;Fullwood MJ
长链非编码RNA（lncRNA）在癌症中起重要作用。它们通过各种基于染色质的机制以及通过与其他RNA种类的串扰参与染色质重塑以及转录和转录后调节。lncRNA可以充当诱饵、支架和增强子RNA。本文综述了lncRNA的特点，包括它们的作用，功能和工作机制，描述了识别和注释lncRNA的方法，并讨论了未来的机会，lncRNA为基础的治疗使用反义寡核苷酸。
Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lncRNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lncRNAs, and discusses future opportunities for lncRNA-based therapies using antisense oligonucleotides.