Endoscopic therapy for Barrett's oesophagus
Endoscopic therapy for Barrett's oesophagus
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DOI：
10.1016/j.bpg.2014.11.007
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发表时间：
2015-02-01
影响因子：
3.2
通讯作者：
Iyer, Prasad G.
中科院分区：
文献类型：
--
作者：
Blevins, Christopher H.;Iyer, Prasad G.
Barrett食管（BO）被认为是通过发育不良（低级别和高级别）发展为食管腺癌，这是一种生存率低的致命癌症。BO内镜治疗的总体目标是消除化生和发育不良的上皮，预防和/或降低进展为OAC的风险。内镜治疗技术可分为两种广泛的互补技术：组织获取（内镜下粘膜切除和内镜下粘膜剥离）和消融。内镜治疗对于粘膜内癌（IMC）、高级别不典型增生（HGD）以及最近治疗低级别不典型增生（LGD）是安全有效的。内镜治疗的挑战正在被认识到，如不完全反应和复发。虽然根除肠化生是内镜治疗的直接目标，但在完全消除肠化生后必须继续监测，以发现和治疗复发。(C) 2014 Elsevier Ltd.版权所有。
Barrett's oesophagus (BO) is thought to progress through the development of dysplasia (low grade and high grade) to oesophageal adenocarcinoma, a lethal cancer with poor survival. The overall goal of endoscopic therapy of BO is to eliminate metaplastic and dysplastic epithelium, to prevent and/or reduce the risk of progression to OAC. Endoscopic therapy techniques can be divided into two broad complementary techniques: tissue acquiring (endoscopic mucosal resection and endoscopic submucosal dissection) and ablative. Endoscopic therapy has been established as safe and effective for the subjects with intra-mucosal cancer (IMC), high-grade dysplasia (HGD) and more recently in treating low-grade dysplasia (LGD). Challenges to endoscopic therapy are being recognized, such as incomplete response and recurrence. While eradication of intestinal metaplasia is the immediate goal of endoscopic therapy, surveillance must continue after complete elimination of intestinal metaplasia, to detect and treat recurrences. (C) 2014 Elsevier Ltd. All rights reserved.