SEQUENCE OF SIMIAN IMMUNODEFICIENCY VIRUS AND ITS RELATIONSHIP TO THE HUMAN IMMUNODEFICIENCY VIRUSES
SEQUENCE OF SIMIAN IMMUNODEFICIENCY VIRUS AND ITS RELATIONSHIP TO THE HUMAN IMMUNODEFICIENCY VIRUSES
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DOI：
10.1038/328539a0
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发表时间：
1987-08-06
期刊：
影响因子：
64.8
通讯作者：
REITZ, MS
中科院分区：
文献类型：
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作者：
FRANCHINI, G;GURGO, C;REITZ, MS
HIV-1（HTLV-III/LAV）1，2，与AIDS（获得性免疫缺陷综合征）3相关的人类逆转录病毒的特征鉴定导致了一组相关的人类和猿猴逆转录病毒的鉴定，它们也感染携带CD 4的T淋巴细胞。来自猕猴的猿猴T淋巴细胞病毒III型（猿猴免疫缺陷病毒）（STLV-IIIMAC）在感染的猕猴中诱导类似于艾滋病的症状4，5，但来自非洲绿色猴（STLV-IIIAGM）6和白眉猴（STLV-IIMM）7，8的分离株在这些动物中似乎是非致病性的。一种与STLV-IIIAGM（HTLV-IV）免疫相关的人类病毒，据报道已从健康人中分离9，已显示与STLV-IHAGM几乎相同10，11，这引起了对这些病毒独立起源的质疑11。本文报道了STLV-IIIAGM的全序列，并分析了它与HIV-1的HTLV-IIIB株、HIV-2 ROD（以前称为LAV-2）12- 15和几种有蹄类慢逆转录病毒基因组的关系。STLV-IIIAGM与HIV-2关系密切，与HIV-1关系较远。
The characterization of HIV-1 (HTLV-III/LAV)1,2, the human retrovirus associated with AIDS (acquired immune deficiency syndrome)3has led to the identification of a group of related human and simian retroviruses which also infect CD4-bearing T lymphocytes. Simian T-lymphotropic virus type III (simian immodeficiency virus) from macaques (STLV-IIIMAC) induces symptoms similar to those of AIDS in infected macaques4,5, but isolates from African green monkeys (STLV-IIIAGM)6and mangabeys (STLV-IIMM)7,8appear to be non-pathogenic in these animals. A human virus immunologically related to STLV-IIIAGM(HTLV-IV), reported to have been isolated from healthy humans9, has been shown to be almost identical to STLV-IHAGM10,11, which has called into question the independent origin of these viruses11. Here we report the complete DNA sequence of STLV-IIIAGMand analyse its relationship with the genomes of the HTLV -IIIBstrain of HIV-1, HIV-2ROD(previously called LAV-2)12–15and several ungulate lentiretroviruses. STLV-IIIAGMand HIV-2 are closely related, and more distantly related to HIV-1.