Horizontal gene transfer in the molecular evolution of mannose PTS transporters.
Horizontal gene transfer in the molecular evolution of mannose PTS transporters.
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甘露糖 PTS 转运蛋白分子进化中的水平基因转移。
DOI：
10.1093/molbev/msi163
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发表时间：
2005
影响因子：
10.7
通讯作者：
F. González
中科院分区：
文献类型：
--
作者：
M. Zúñiga;I. Comas;Raquel Linaje;V. Monedero;M. J. Yebra;C. D. Esteban;J. Deutscher;G. Pérez;F. González
磷酸烯醇丙酮酸：碳水化合物磷酸转移酶系统（PTS）是迄今为止唯一的基团易位转运系统的例子。PTS转运蛋白仅存在于细菌中，根据其序列和结构可分为6类。我们分析了甘露糖类PTS转运体的进化。这些转运蛋白在细菌中的分布有限，主要由与动物有关的物种所携带。结果表明，这些基因经历了一个复杂的进化史，包括广泛的水平基因转移事件、复制和非同源位移。系统发育分析揭示了早期的多样化，专门针对不同的运输能力，但这些事件也发生在相对较近的时间。此外，这些转运体可以进一步分为七个组，这种划分与它们的运输能力有关。最后，考虑到基因组背景，我们提出了一些未表征的PTS转运蛋白的假定功能作用。甘露糖类PTS转运体的功能作用和分布表明，它们的扩张可能在动物与某些细菌之间建立共生关系中发挥了重要作用。
The phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) represents hitherto the only example of group translocation transport systems. PTS transporters are exclusively found in bacteria and can be grouped on the basis of sequence and structure into six classes. We have analyzed the evolution of mannose-class PTS transporters. These transporters have a limited distribution among bacteria being mostly harbored by species associated to animals. The results obtained indicate that these genes have undergone a complex evolutionary history, including extensive horizontal gene transfer events, duplications, and nonorthologous displacements. The phylogenetic analysis revealed an early diversification to specialize in different transport capabilities, but these events have also occurred relatively recently. In addition, these transporters can be further divided into seven groups and this division correlates with their transport capabilities. Finally, the consideration of the genomic context allowed us to propose putative functional roles for some uncharacterized PTS transporters. The functional role and distribution of mannose-class PTS transporters suggest that their expansion may have played a significant role in the establishment of symbiotic relationships between animals and some bacteria.
微生物基因组中编码转运蛋白的旁系同源基因。
影响因子：
2.6
作者：
SaierJr,MH;Paulsen,IT
通讯作者：
Paulsen,IT
影响因子：
6.8
作者：
Reizer, J;Saier, MH
通讯作者：
Saier, MH
影响因子：
2.6
作者：
Hu, KY;Saier, MH
通讯作者：
Saier, MH