Presence of platelet-activating factor in nasal polyps and eosinophils
Presence of platelet-activating factor in nasal polyps and eosinophils
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DOI：
10.1080/003655402/000028064
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发表时间：
2002-01-01
影响因子：
1.4
通讯作者：
Yamashita, T
中科院分区：
文献类型：
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作者：
Furukawa, M;Ogura, M;Yamashita, T
据报道，血小板活化因子(PAF)在过敏和炎症反应中发挥作用，但其在鼻息肉发病机制中的作用尚不清楚。在这项研究中，我们检测了鼻息肉个体制剂中的PAF和多肽白三烯(PeptLTS)。在所有制剂中，PAF的含量都远大于多肽。鼻息肉根据嗜酸性粒细胞浸润的严重程度分为两组：重度组(嗜酸性粒细胞计数大于或等于50/mm(2))和轻度组(嗜酸性粒细胞计数
Platelet-activating factor (PAF) has been reported to play a role in allergy and inflammatory reactions but its role in the pathogenesis of nasal polyps remains unclear. In this study, we examined both PAF and peptide leukotrienes (peptLTS) in individual preparations from nasal polyps. The amounts of PAF were much greater than those of peptLTs in all preparations. Nasal polyps were divided into two groups according to the severity of eosinophil infiltration: a severe group (eosinophil count greater than or equal to 50/mm(2)) and a mild group (eosinophil count