PEGylated polymers for medicine: from conjugation to self-assembled systems
PEGylated polymers for medicine: from conjugation to self-assembled systems
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DOI：
10.1039/b920570p
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Emrick, Todd
中科院分区：
文献类型：
--
作者：
Joralemon, Maisie J.;McRae, Samantha;Emrick, Todd
合成聚合物在许多科学和技术领域改变了社会，包括最近在医学上的突破。合成聚合物现在为药物递送提供了独特和多功能的平台，因为它们可以被“定制”为植入物、医疗器械和可注射聚合物-药物缀合物。然而，虽然目前使用的几种治疗性蛋白质和小分子药物已受益于合成聚合物，但基于聚合物的药物递送平台的全部潜力尚未实现。本文综述了合成聚合物在药物递送中的一般优势和具体情况，重点介绍了聚乙二醇化在聚合物结构，自组装和缀合技术的背景下，显示出相当大的有效性和/或潜在的治疗。
Synthetic polymers have transformed society in many areas of science and technology, including recent breakthroughs in medicine. Synthetic polymers now offer unique and versatile platforms for drug delivery, as they can be "io-tailored'' for applications as implants, medical devices, and injectable polymer-drug conjugates. However, while several currently used therapeutic proteins and small molecule drugs have benefited from synthetic polymers, the full potential of polymer-based drug delivery platforms has not yet been realized. This review examines both general advantages and specific cases of synthetic polymers in drug delivery, focusing on PEGylation in the context of polymer architecture, self-assembly, and conjugation techniques that show considerable effectiveness and/or potential in therapeutics.