IMBA Professional Plus: A flexible approach to internal dosimetry
IMBA Professional Plus: A flexible approach to internal dosimetry
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DOI：
10.1093/rpd/ncl171
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发表时间：
2007-01-01
影响因子：
1
通讯作者：
James, A. C.
中科院分区：
文献类型：
--
作者：
Birchall, A.;Puncher, M.;James, A. C.
IMBA （Integrated Modules for Bioassay Analysis）是一套软件模块，可实现当前ICRP生物动力学和剂量学模型，用于估计摄入量和剂量。IMBA模块已经通过了广泛的质量保证，现在被英国各地的批准剂量测定服务机构用于常规正式剂量评估。HPA继续开发IMBA模块。此外，由美国和加拿大的组织赞助的几个项目已经导致了定制用户友好界面（IMBA专家（TM）“版本”）的发展。这使得用户不仅可以使用标准的ICRP模型，而且还可以更改ICRP默认值中的许多参数值，并将复杂的数据处理技术应用于内部剂量计算。这些方法包括：用最大似然法拟合测量数据；使用多种慢性和急性摄入；同时处理不同的数据类型，如尿液、粪便和整个身体。由于用户的反馈，这些接口得到了进一步的改进，并于2004年1月开发了通用的“现成”产品IMBA Professional。新版本IMBA Professional Plus于2005年4月发布，它比以前的软件更快，功能更强大。本文的目的是描述IMBA Professional Plus的功能，以及所使用的数学方法。
IMBA (Integrated Modules for Bioassay Analysis) is a suite of software modules that implement the current ICRP biokinetic and dosimetric models for estimation of intakes and doses. The IMBA modules have gone through extensive quality assurance, and are now used for routine formal dose assessment by Approved Dosimetry Services throughout the UK. HPA has continued to develop the IMBA modules. In addition, several projects, sponsored by organisations both in the USA and in Canada, have resulted in the development of customised user-friendly interfaces (IMBA Expert (TM) 'editions'). These enable users not only to use the standard ICRP models, but also to change many of the parameter values from ICRP defaults, and to apply sophisticated data handling techniques to internal dose calculations. These include: fitting measurement data with the maximum likelihood method; using multiple chronic and acute intakes; and dealing with different data types, such as urine, faeces and whole body simultaneously. These interfaces were improved further as a result of user-feedback, and a general 'off-the-shelf' product, IMBA Professional, was developed and made available in January 2004. A new version, IMBA Professional Plus, was released in April 2005, which is both faster and more powerful than previous software. The aim of this paper is to describe the capabilities of IMBA Professional Plus, and the mathematical methods used.