THE CHEMOTHERAPY OF ONCHOCERCIASIS .2. QUANTITATION OF THE CLINICAL REACTION TO MICROFILARICIDES
THE CHEMOTHERAPY OF ONCHOCERCIASIS .2. QUANTITATION OF THE CLINICAL REACTION TO MICROFILARICIDES
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DOI：
10.1080/00034983.1980.11687330
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发表时间：
1980-01-01
影响因子：
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通讯作者：
AWADZI, K
中科院分区：
文献类型：
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作者：
AWADZI, K
加纳北方稀树草原地区塔马利盘尾丝虫病化学治疗研究中心设计了一种对杀微丝蚴剂临床反应进行定量的方法。该方法采用常见反应（排尿、皮疹、腺体反应、肌肉骨骼、发热和心血管）和内置加权因子的评分系统。尽管该方法耗时且需要对患者进行密切、持续的观察，但它应允许对服用相同药物的相似或不同剂量或在比较基础上服用不同药物的个体患者或患者组的临床反应严重程度做出更具体的声明。建议将对杀微丝蚴剂临床反应的定量方法作为评估用于控制盘尾丝虫病的任何药物的基本部分。
A method of quantitation of the clinical reaction to microfilaricides was devised at the Onchocerciasis Chemotherapeutic Research Centre at Tamale, in the savanna area of Northern Ghana. The method employs commonly occurring reactions (puritus, rash, glandular reactions, musculoskeletal, febrile and cardiovascular) and a scoring system with a built-in weighting factor. Although the method is time-consuming and requires close, continuous observation of patients, it should permit more specific statements to be made about the severity of clinical reactions in individual patients or in groups of patients taking similar or different doses of the same drug or taking different drugs on a comparative basis. It is recommended that quantitative methods of the clinical reaction to microfilaricides form a basic part of the assessment of any drug used in the control of onchocerciasis.