TOWARD PROTEIN TERTIARY STRUCTURE RECOGNITION BY MEANS OF ASSOCIATIVE MEMORY HAMILTONIANS
TOWARD PROTEIN TERTIARY STRUCTURE RECOGNITION BY MEANS OF ASSOCIATIVE MEMORY HAMILTONIANS
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DOI：
10.1126/science.246.4928.371
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发表时间：
1989-10-20
期刊：
影响因子：
56.9
通讯作者：
WOLYNES, PG
中科院分区：
文献类型：
--
作者：
FRIEDRICHS, MS;WOLYNES, PG
联想记忆和自旋玻璃的统计力学为设计蛋白质折叠的哈密顿量提供了方法。基于疏水性模式的关联记忆哈密顿量被证明具有很大的召回能力，并能够识别中等变异序列的三级结构。
The statistical mechanics of associative memories and spin glasses suggests ways to design Hamiltonians for protein folding. An associative memory Hamiltonian based on hydrophobicity patterns is shown to have a large capacity for recall and to be capable of recognizing tertiary structure for moderately variant sequences.