Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity
Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity
复制标题
DOI：
10.1101/lm.1971110
复制
发表时间：
2011-01-01
影响因子：
2
通讯作者：
Stark, Craig E. L.
中科院分区：
文献类型：
--
作者：
Lacy, Joyce W.;Yassa, Michael A.;Stark, Craig E. L.
为相似事件产生和保持不同的(正交)神经表征对于避免长期记忆中的干扰至关重要。最近，我们的实验室首次提供了人类CA3/Dentate中分离样信号的证据。在这里，我们通过参数改变输入(相似性)的变化来扩展这一点，同时使用高分辨率fMRI监测CA1和CA3/Dentate信号的分离和完成样信号。在CA1中，活动以分级方式变化，以响应投入变化的增加。相反，CA3/Dentate表现出对输入的微小变化高度敏感的阶梯式传递函数。
Producing and maintaining distinct (orthogonal) neural representations for similar events is critical to avoiding interference in long-term memory. Recently, our laboratory provided the first evidence for separation-like signals in the human CA3/dentate. Here, we extended this by parametrically varying the change in input (similarity) while monitoring CA1 and CA3/dentate for separation and completion-like signals using high-resolution fMRI. In the CA1, activity varied in a graded fashion in response to increases in the change in input. In contrast, the CA3/dentate showed a stepwise transfer function that was highly sensitive to small changes in input.