A Robust Oxygen Microbubble Radiosensitizer for Iodine-125 Brachytherapy.
A Robust Oxygen Microbubble Radiosensitizer for Iodine-125 Brachytherapy.
复制标题
用于 Iodine-125 近距离放射治疗的强大氧气微泡放射增敏剂
DOI：
10.1002/advs.202002567
复制
发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Zhang F
中科院分区：
文献类型：
--
作者：
Peng S;Song R;Lin Q;Zhang Y;Yang Y;Luo M;Zhong Z;Xu X;Lu L;Yao S;Zhang F
碘-125（125 I）近距离放射治疗是一种很有前途的放射治疗形式，越来越多地应用于各种实体肿瘤的临床治疗。然而，实体瘤中极度缺氧的微环境可导致缺氧诱导的对125 I近距离放射治疗的放射抗性，导致治疗无效。在这项研究中，目的是使用超声激活氧微泡进行125 I近距离放射治疗，以敏化实体瘤中的缺氧区域。开发了一种改良的乳剂冷冻干燥方法，用于制备可冻干储存并在给药前易于原位复溶的微泡。通过向氧气中添加六氟化硫来改变微泡的填充气体，使得获得的O2/SF6微泡（OS MB）实现比氧气微泡长得多的半衰期（>3倍）。在携带鼻咽癌（CNE 2）肿瘤的小鼠中测试OS MB，并且由超声辐射诱导的OS MB的氧递送立即缓解缺氧。近距离放射治疗联合超声触发OS MB的治疗后结果显示，与单独近距离放射治疗相比，治疗效果大大提高，说明使用开发的OS MB进行超声介导的氧气输送是改善低氧肿瘤125 I近距离放射治疗疗效的一种有前景的策略。开发肿瘤特异性超声激活氧微泡以使缺氧肿瘤细胞对125 I近距离放射治疗敏感。微泡冻干保存，给药前易于原位重构，通过将六氟化硫加入氧气中，具有更好的稳定性。使用微泡进行超声介导的氧气输送，显示出125 I近距离放射治疗低氧肿瘤的疗效大大改善。
Iodine‐125 (125I) brachytherapy, a promising form of radiotherapy, is increasingly applied in the clinical treatment of a wide range of solid tumors. However, the extremely hypoxic microenvironment in solid tumors can cause hypoxia‐induced radioresistance to 125I brachytherapy, resulting in therapeutic inefficacy. In this study, the aim is to sensitize hypoxic areas in solid tumors using ultrasound‐activated oxygen microbubbles for 125I brachytherapy. A modified emulsion freeze‐drying method is developed to prepare microbubbles that can be lyophilized for storage and easily reconstituted in situ before administration. The filling gas of the microbubbles is modified by the addition of sulfur hexafluoride to oxygen such that the obtained O2/SF6 microbubbles (OS MBs) achieve a much longer half‐life (>3×) than that of oxygen microbubbles. The OS MBs are tested in nasopharyngeal carcinoma (CNE2) tumor‐bearing mice and oxygen delivery by the OS MBs induced by ultrasound irradiation relieve hypoxia instantly. The post‐treatment results of brachytherapy combined with the ultrasound‐triggered OS MBs show a greatly improved therapeutic efficacy compared with brachytherapy alone, illustrating ultrasound‐mediated oxygen delivery with the developed OS MBs as a promising strategy to improve the therapeutic outcome of 125I brachytherapy in hypoxic tumors. Tumor‐specific ultrasound‐activated oxygen microbubbles are developed to sensitize hypoxic tumor cells for 125I brachytherapy. The microbubbles, lyophilized for storage and easily reconstituted in situ before administration, have much better stability by the addition of sulfur hexafluoride into oxygen. Ultrasound‐mediated oxygen delivery with the microbubbles demonstrate a greatly improved therapeutic outcome of 125I brachytherapy in hypoxic tumors.
登录
查看更多内容
影响因子：
2.3
作者：
Delaney, Lauren J.;Ciraku, Lorela;Eisenbrey, John R.
通讯作者：
Eisenbrey, John R.
影响因子：
19
作者：
Ackerman, Daniel;Simon, M. Celeste
通讯作者：
Simon, M. Celeste
影响因子：
15.1
作者：
Chu, Chengyan;Lyu, Xiaoming;Hu, Xianglong
通讯作者：
Hu, Xianglong
DOI：
10.1016/j.ijrobp.2009.06.091
发表时间：
2010-03-01
影响因子：
7
作者：
Marks, Lawrence B.;Bentzen, Soren M.;Deasy, Joseph O.;Kong, Feng-Ming (Spring);Bradley, Jeffrey D.;Vogelius, Ivan S.;El Naqa, Issam;Hubbs, Jessica L.;Lebesque, Joos V.;Timmerman, Robert D.;Martel, Mary K.;Jackson, Andrew
通讯作者：
Jackson, Andrew
影响因子：
17.1
作者：
Goel S;Ni D;Cai W
通讯作者：
Cai W