Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features
Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features
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DOI：
10.1016/j.eururo.2006.11.020
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发表时间：
2007-08-01
期刊：
影响因子：
23.4
通讯作者：
Raaphorst, Frank M.
中科院分区：
文献类型：
--
作者：
van Leenders, Geert J. L. H.;Dukers, Danny;Raaphorst, Frank M.
目的：多梳族蛋白（Polycomb group，PcG）参与细胞身份的维持和增殖。蛋白EZH2在播散性前列腺癌中过表达，暗示PcG复合物在肿瘤进展中的作用。在这项研究中，我们评估了两个PcG复合物的八个成员在临床病理定义的前列腺癌cancer.Methods的表达：两个PcG蛋白复合物PRC2（EZH2，EED，YY1）和PRC1（BMI1 RING1，HPH1，HPC 1，HPC 2）的组成部分在114例前列腺癌患者的组织微阵列中进行了化学鉴定。结果：BMI1、RING1、HPC 1和HPH 1在正常和恶性前列腺上皮中均呈高表达，而EZH2仅在正常和恶性前列腺上皮中表达。
Objectives: Polycomb group (PcG) proteins are involved in maintenance of cell identity and proliferation. The protein EZH2 is overexpressed in disseminated prostate cancer, implicating a role of PcG complexes in tumor progression. In this study, we evaluated the expression of eight members of both PcG complexes in clinicopathologically defined prostate cancer.Methods: Components of both PcG protein complexes PRC2 (EZH2, EED, YY1) and PRC1 (BMI1 RING1, HPH1, HPC1, HPC2) were immunohistochemically identified in tissue microarrays of 114 prostate cancer patients. Protein expression was semi-quantitatively scored and correlated with pathologic parameters and recurrence of prostate-specific antigen (PSA).Results: Whereas BMI1, RING1, HPC1 and HPH1 were all abundantly present in normal and malignant prostate epithelium, expression of EZH2 occurred in only