Dynamic Expression of the Slit-Robo GTPase Activating Protein Genes during Development of the Murine Nervous System
Dynamic Expression of the Slit-Robo GTPase Activating Protein Genes during Development of the Murine Nervous System
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DOI：
10.1002/cne.21955
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发表时间：
2009-03-10
影响因子：
2.5
通讯作者：
Rappold, Gudrun
中科院分区：
文献类型：
--
作者：
Bacon, Claire;Endris, Volker;Rappold, Gudrun
我们研究了三个已知的Slit-Robo GT3激活蛋白（srGAP）基因在小鼠神经系统中的表达，使用原位杂交。这三个基因在小鼠神经系统的胚胎和出生后早期发育过程中表达，在嗅觉系统，眼睛，前脑和中脑结构，小脑，脊髓和背根神经节，我们讨论有关Slit-Robo表达模式和信号通路中显示出不同的表达模式。我们还报道了中枢神经系统（CNS）许多不同组织中神经元分化区和神经发生脑室区中的srGAP 2表达。与srGAP 2和srGAP 3相比，srGAP 1在大多数CNS组织中的表达开始较晚。我们认为，这些差异的表达点这三个基因在神经组织的发展之间的功能差异。J. Comp.神经元513：224- 236，2009。(c)2009 Wiley-Liss，Inc.
We investigated the expression of the three known Slit-Robo GTPase activating protein (srGAP) genes in the developing murine nervous system using in situ hybridization. The three genes are expressed during embryonic and early postnatal development in the murine nervous system, showing a distinct pattern of expression in the olfactory system, the eye, forebrain and midbrain structures, the cerebellum, the spinal cord, and dorsal root ganglia, which we discuss in relation to Slit-Robo expression patterns and signaling pathways. We also report srGAP2 expression in zones of neuronal differentiation and srGAP3 in ventricular zones of neurogenesis in many different tissues of the central nervous system (CNS). Compared to srGAP2 and srGAP3, the onset of srGAP1 expression is later in most CNS tissues. We propose that these differences in expression point to functional differences between these three genes in the development of neural tissues. J. Comp. Neurol. 513: 224-236,2009. (c) 2009 Wiley-Liss, Inc.