Alterations in the expression of homing-associated molecules at the maternal/fetal interface during the course of pregnancy
Alterations in the expression of homing-associated molecules at the maternal/fetal interface during the course of pregnancy
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DOI：
10.1095/biolreprod66.2.333
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发表时间：
2002-02-01
影响因子：
3.6
通讯作者：
Butcher, EC
中科院分区：
文献类型：
--
作者：
Kruse, A;Martens, N;Butcher, EC
最吸引人的免疫学问题之一是，遗传上不同的胎儿如何能够在母亲体内生存和发育，而不会引起免疫排斥反应。妊娠子宫发生快速的形态和功能变化，这些变化可能会影响妊娠不同阶段母体/胎儿界面局部免疫反应的性质。我们假设存在专门的机制来控制母体白细胞亚群进入蜕膜，并且这些机制在妊娠过程中受到调节。在最初胎盘发育的关键时期，母体/胎儿界面显示出与高度分化的血管相关的微环境领域的无与伦比的区室化，这些血管以非重叠模式表达血管地址素，并招募被认为支持、调节和调节滋养层侵袭的专门白细胞亚群（单核细胞、颗粒状子宫腺细胞和粒细胞）。在妊娠的这个时候，最引人注目的观察结果之一是淋巴细胞几乎完全被排除在母体/胎儿界面之外。妊娠后半期的特征是微环境特化的部分丧失和基底蜕膜内血管特异性的不同转换，与募集的白细胞群体的急剧变化平行（例如，淋巴细胞，尤其是T细胞的显著流入）。在长期妊娠子宫，所有的血管地址素的表达显着下降，只有弱染色的母体血管节段仍然存在。这些部分可以定义在术语蜕膜，其中包含显着很少的母体白细胞总体上极低的残留流量的网站。我们的研究结果表明，母亲/胎儿界面代表了一种情况，其中白细胞贩运的精细调节，允许进入专门的白细胞亚群，可能在怀孕期间的免疫调节中发挥重要作用。
One of the most fascinating immunologic questions is how the genetically distinct fetus is able to survive and develop within the mother without provoking an immune rejection response. The pregnant uterus undergoes rapid morphological and functional changes, and these changes may influence the nature of local immune responses at the maternal/fetal interface at different stages of gestation. We hypothesized that specialized mechanisms exist to control access of maternal leukocyte subsets to the decidua and that these mechanisms are modulated during the course of pregnancy. At the critical period of initial placenta development, the maternal/fetal interface displays an unparalleled compartmentalization of microenvironmental domains associated with highly differentiated vessels expressing vascular addressins in nonoverlapping patterns and with recruitment of specialized leukocyte subsets (monocytes, granulated metrial gland cells, and granulocytes) thought to support, modulate, and regulate trophoblast invasion. One of the most striking observations at this time of gestation is the almost complete exclusion of lymphocytes from the maternal/fetal interface. The second half of pregnancy is characterized by a partial loss of microenvironmental specialization and different switches in vascular specificity within the decidua basalis, paralleling dramatic changes in the populations of recruited leukocytes (e.g., a striking influx of lymphocytes, especially T cells). In the term pregnant uterus, the expression of all vascular addressins decreased dramatically; only weakly staining maternal vascular segments remained. These segments may define sites of extremely low residual traffic in the term decidua, which contains remarkably few maternal leukocytes overall. Our results suggest that the maternal/fetal interface represents a situation in which leukocyte trafficking is exquisitely regulated to allow entry of specialized leukocyte subsets that may play a fundamental role in immune regulation during pregnancy.