CD2 signaling in T cells involves tyrosine phosphorylation and activation of the Tec family kinase, EMT/ITK/TSK.
CD2 signaling in T cells involves tyrosine phosphorylation and activation of the Tec family kinase, EMT/ITK/TSK.
复制标题
T 细胞中的 CD2 信号传导涉及酪氨酸磷酸化和 Tec 家族激酶 EMT/ITK/TSK 的激活。
DOI：
10.1093/intimm/8.11.1707
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发表时间：
1996
影响因子：
4.4
通讯作者：
Dupont,B
中科院分区：
文献类型：
--
作者：
King,PD;Sadra,A;Han,A;Liu,XR;Sunder-Plassmann,R;Reinherz,EL;Dupont,B
Ligation of the CD2 cell surface glycoprotein expressed on T lymphocytes and NK cells induces protein tyrosine phosphorylation and activation of the Src kinases, LCK and FYN. We show here that in Jurkat T leukemia cells and in peripheral blood T cells, CD2 stimulation also leads to tyrosine phosphorylation and activation of the Tec family kinase, EMThTKITSK. Activation of EMT by CD2 was induced by mitogenic pairs of CD2 mAb, certain single CD2 mAb followed by secondary antibody cross-linking, and CD58-bearing sheep red blood cells. With the use of different Jurkat cell mutants it was demonstrated that CD2-mediated activation of EMT required expression of LCK, but did not require surface expression of the CD3 ζ chain. Receptor-mediated activation of LCK does not in itself lead to activation of this Tec kinase since induction of LCK by ligation of CD4 or CD5 did not result in activation of EMT. The activation of EMT during CD2 signaling suggests an important role for this kinase in CD2 co-stimulation of T cell responses.
