Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats
Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats
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DOI：
10.1016/j.neulet.2011.02.030
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发表时间：
2011-04-15
影响因子：
2.5
通讯作者：
Mao, Qing-Qiu
中科院分区：
文献类型：
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作者：
Huang, Zhen;Zhong, Xiao-Ming;Mao, Qing-Qiu
最近，已经开发了一种使用外源性皮质酮（CORT）给药的抑郁症大鼠模型。本研究旨在探讨姜黄素对皮质醇诱导的大鼠抑郁模型的抗抑郁样作用及其可能机制。结果表明，3周CORT注射导致抑郁样行为的大鼠，在强迫游泳试验中的蔗糖消耗量显着减少和不动时间增加。重复注射CORT也显著降低了大鼠海马和额叶皮质中的脑源性神经营养因子（BDNF）蛋白水平。用姜黄素治疗大鼠显著抑制了由重复CORT注射引起的抑郁样行为和脑BDNF水平的降低。结果表明，姜黄素在皮质醇治疗的大鼠中产生抗抑郁样作用，这可能是通过增加海马和额叶皮质中的BDNF表达介导的。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
A rat model of depression has been recently developed using exogenous corticosterone (CORT) administration. This study aimed to examine the antidepressant-like effect and the possible mechanisms of curcumin in a CORT-induced depression model in rats. The results showed that 3-week CORT injections caused depression-like behavior in rats, as indicated by the significant decrease in sucrose consumption and increase in immobility time in the forced swim test. Repeated CORT injections also significantly decreased brain-derived neurotrophic factor (BDNF) protein levels in the hippocampus and frontal cortex of the rats. Treatment of the rats with curcumin significantly suppressed the depression-like behavior and the decrease in brain BDNF levels induced by the repeated CORT injections. The results suggest that curcumin produces an antidepressant-like effect in CORT-treated rats, which is possibly mediated by increasing BDNF expression in the hippocampus and frontal cortex. (C) 2011 Elsevier Ireland Ltd. All rights reserved.