Correlation of cortisol in 1-cm hair segment with salivary cortisol in human: hair cortisol as an endogenous biomarker
Correlation of cortisol in 1-cm hair segment with salivary cortisol in human: hair cortisol as an endogenous biomarker
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DOI：
10.1515/cclm.2011.706
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发表时间：
2011-01-01
影响因子：
6.8
通讯作者：
Lu, Zuhong
中科院分区：
文献类型：
--
作者：
Xie, Qiaozhen;Gao, Wei;Lu, Zuhong
背景资料：人发中皮质醇水平可作为一种内源性生物标志物，用于回顾性评估长期中枢下丘脑-垂体-肾上腺活动。然而，没有直接证据支持血液相关的扩散是人类毛发皮质醇的生物内源性来源。本研究旨在验证皮质醇在1厘米的头发片段和唾液皮质醇在健康human.Methods：我们收集了三个唾液样本，从同一参与者在时间1，时间2（1周后）和时间3（2周后），头发4周后的直接相关性。用高效液相色谱-串联质谱法测定1cm毛发和唾液中皮质醇的含量。结果：唾液皮质醇在时间I和时间2显著相关（r =0.514，p = 0.003），但与时间点3的结果不一致（r = 0.187，p = 0.305）;并且时间2的一个与时间3的一个显著相关（r = 0.380，p = 0.032）。头发皮质醇与唾液皮质醇在时间2（r = 0.389，p < 0.05）和平均唾液皮质醇（r = 0.383，p < 0.05）显著相关。
Background: Cortisol level in human hair would be an endogenous biomarker for the retrospective assessment of long-term central hypothalamo-pituitary-adrenal activity. However, no direct evidence supports that blood-related diffusion is a biologically endogenous source of hair cortisol in humans. The present study aims to validate the direct correlation between cortisol in 1-cm hair segments and salivary cortisol in healthy humans.Methods: We collected three saliva samples from the same participant at Time 1, Time 2 (1 week later) and Time 3 (2 weeks later), and hair 4 weeks later. Cortisol levels in I-cm hair segments and saliva were determined with high performance liquid chromatography tandem mass spectrometryResults: Salivary cortisol at Time I was significantly associated with that at Time 2 (r =0.514, p = 0.003), but not with that at Time 3 (r = 0.187, p = 0.305); and the one at Time 2 was significantly associated with that at Time 3 (r = 0.380, p = 0.032). Hair cortisol was significantly correlated with salivary cortisol at Time 2 (r = 0.389, p < 0.05) and average salivary cortisol (r = 0.383, p < 0.05) from three sampling.Conclusions: Our results confirmed that blood-related diffusion mechanism is a biologically endogenous source of hair cortisol.