A MUTATION IN THE BETA(3)-ADRENERGIC RECEPTOR GENE IS ASSOCIATED WITH OBESITY AND HYPERINSULINEMIA IN JAPANESE SUBJECTS
A MUTATION IN THE BETA(3)-ADRENERGIC RECEPTOR GENE IS ASSOCIATED WITH OBESITY AND HYPERINSULINEMIA IN JAPANESE SUBJECTS
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DOI：
10.1006/bbrc.1995.2500
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发表时间：
1995-10-13
影响因子：
3.1
通讯作者：
KADOWAKI, T
中科院分区：
文献类型：
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作者：
KADOWAKI, H;YASUDA, K;KADOWAKI, T
对350名日本受试者β(3)-肾上腺素能受体(β(3)AR)基因Trp 61 Arg突变进行了研究。该突变与非胰岛素依赖型糖尿病(NIDDM)无关。在无糖尿病的受试者中，该突变纯合子个体的体重指数显著高于正常等位基因纯合子个体(24.7+/-1.4vs22.1/-0.2 kg/m(2)，p=0.009)。此外，肥胖者(BMI>；26.4)的突变等位基因频率显著高于非肥胖者(BMI
The Trp 61 Arg mutation in the beta(3)-adrenergic receptor (beta(3)AR) gene was investigated in 350 Japanese subjects. This mutation was not associated with non-insulin-dependent diabetes mellitus (NIDDM). In 191 subjects without NIDDM, body mass index (BMI) was significantly higher in subjects homozygous for this mutation than in those homozygous for the normal allele (24.7+/-1.4 vs 22.1+/-0.2 kg/m(2), p=0.009). Moreover, the frequency of the mutant allele in obese subjects (BMI>26.4) was significantly higher than that in non-obese subjects (BMI