Food intake, body weight gain, and body composition of the young obese (ob/ob) mouse.
Food intake, body weight gain, and body composition of the young obese (ob/ob) mouse.
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年轻肥胖 (ob/ob) 小鼠的食物摄入量、体重增加和身体成分。
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发表时间：
1977
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影响因子：
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通讯作者：
Gilbert A. Leveille
中科院分区：
文献类型：
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作者：
Pi;D. Romsos;Gilbert A. Leveille
林丕耀ROMSOS ANGGILBERT A. LEVEILLE密歇根州立大学食品科学与人类营养系，东兰辛，密歇根48824摘要在7至56日龄的肥胖（ob/ob）小鼠中获得食物摄入和体重增加的估计值。从7天到21天每天估计牛奶摄入量;肥胖和瘦小鼠之间没有差异。从14天到21天，肥胖小鼠比瘦小鼠增加更多的体重。在21天大的时候，肥胖小鼠的尸体含有大约两倍于瘦小鼠尸体的脂肪，而蛋白质含量没有差异。小鼠在21日龄时断奶，并单独饲喂普通饲料或高脂肪饲料。在断奶后的头几天里，肥胖的雄性比瘦的雄性消耗更少的食物。在大约28至35天的年龄后，肥胖小鼠比瘦小鼠消耗更多的食物并增加更多的体重。在56日龄时，肥胖小鼠体内脂肪含量是瘦小鼠的4至5倍，但体内蛋白质含量明显低于瘦小鼠。在断奶后的5周内，肥胖小鼠将饮食中的能量转化为身体能量的能力是瘦小鼠的3 - 4倍，而肥胖小鼠只消耗了20 - 40%的能量。与此同时，肥胖小鼠将饮食中的蛋白质转化为身体蛋白质的比例仅为瘦小鼠的70%。高脂饮食显著提高肥胖大鼠的表观能量效率。目前的研究表明，能量代谢的改变，以及蛋白质代谢，可能在这些小鼠肥胖的发展中发挥重要作用。食欲过盛可能是次要的。J.营养一百零七：1715-1723，1977.索引关键词食物摄入、体重增加、身体组成、肥胖、肥胖小鼠遗传性肥胖啮齿动物已经在老年动物中出现（1，8），在关于年轻肥胖研究的食物摄入数据中，很少被广泛用作动物模型（1）。在大多数老鼠身上。营养在研究中可能的作用，成年动物已经被用于肥胖综合征的早期发展。然而，最近的证据表明，该综合征尚未阐明，代谢改变可能已经发生。本研究旨在这些动物的早期发展。在低食物摄入和生长模式的遗传性肥胖（ob/ob）小鼠中，肥胖和瘦小鼠从1到8周增加体脂肪浓度（2，3）年龄。在3周龄断奶前，
PI-YAO LIN, DALE R. ROMSOS ANDGILBERT A. LEVEILLEFood Science & Human Nutrition Department,Michigan State University, East Lansing, Michigan 48824ABSTRACT Estimates of food intake and body weight gain were obtained in obese (ob/ob) mice from 7 to 56 days of age. Milk intake wasestimated daily from 7 to 21 days of age; there were no differences betweenobese and lean mice. From 14 to 21 days of age, obese mice gained morebody weight than lean mice. At 21 days of age, the carcasses of obese micecontained about twice as much fat as the carcasses of lean mice did,whereas the protein content was not different. Mice were weaned at 21days of age, and individually fed a stock diet or a high-fat diet. During thefirst several days after weaning, obese males consumed less food than didthe lean males. After approximately 28 to 35 days of age, obese mice consumed more food and gained more weight than lean mice. At 56 days ofage, obese mice contained 4 to 5 times as much body fat as did lean mice,but contained significantly less body protein than lean mice. For the 5week post-weaning period, obese mice converted 3 to 4 times more dietaryenergy to body energy than did lean mice, whereas obese mice consumedonly 20 to 40% more energy. At the same time, obese mice converted onlyabout 70% as much dietary protein to body protein as did lean mice. Thehigh-fat diet markedly enhanced the apparent energy efficiency in obesemice. The present studies suggest that alterations in energy metabolism,as well as in protein metabolism, may play an important role in the development of obesity in these mice. Hyperphagia may be of secondary importance. J. Nutr. 107: 1715-1723, 1977.INDEXING KEY WORDS food intake •body weight gain •bodycomposition •obesity •ob/ob miceGenetically obese rodents have been in older animals (1, 8), there is a paucityutilized extensively as animal models in of data on food intake of the young obeseobesity studies (1). In most of those mouse. The possible role of nutrition instudies, adult animals have been used, the early development of the obese syn-However, recent evidence suggests that drome has not been elucidated,metabolic alterations may already be prA¨s- The present study was designed to fol-ent in these animals at an early age. In low the food intake and growth pattern ofthe genetically obese (ob/ob) mouse, an obese and lean mice from 1 to 8 weeks ofincreased body fat concentration (2, 3) age. Before weaning at 3 weeks of age,and adipocyte cell size (4), a decreased