Synthesis of coumestan derivatives via FeCl3-mediated oxidative ring closure of 4-hydroxy coumarins.
Synthesis of coumestan derivatives via FeCl3-mediated oxidative ring closure of 4-hydroxy coumarins.
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DOI：
10.1021/jo2000644
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发表时间：
2011-03
期刊：
影响因子：
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通讯作者：
L. Tang;Y. Pang;Q. Yan;Liuqing Shi;Jianhui Huang;Yunfei Du;K. Zhao
中科院分区：
文献类型：
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作者：
L. Tang;Y. Pang;Q. Yan;Liuqing Shi;Jianhui Huang;Yunfei Du;K. Zhao
发展了一种简便、有效的合成香豆素类似物的方法。基础策略涉及FeCl（3）介导的4-羟基-3-苯基-2H-色烯-2-酮衍生物的直接分子内氧化成环。利用该合成方案，从容易获得的试剂方便地获得各种香豆素衍生物。
A concise and efficient approach to the syntheses of coumestan analogues has been developed. The underpinning strategy involves a FeCl(3)-mediated direct intramolecular oxidative annellation of 4-hydroxy-3-phenyl-2H-chromen-2-one derivatives. Utilizing this synthetic protocol, a variety of coumestan derivatives were conveniently obtained from readily available reagents.