SYMPATHETIC DENERVATION IMPAIRS RESPONSES OF BROWN ADIPOSE-TISSUE TO VMH STIMULATION
SYMPATHETIC DENERVATION IMPAIRS RESPONSES OF BROWN ADIPOSE-TISSUE TO VMH STIMULATION
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DOI：
10.1152/ajpregu.1986.251.5.r1005
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发表时间：
1986-11-01
影响因子：
--
通讯作者：
SHIMAZU, T
中科院分区：
文献类型：
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作者：
MINOKOSHI, Y;SAITO, M;SHIMAZU, T
在麻醉大鼠上，观察了肩胛间棕色脂肪组织（IBAT）去神经后对电刺激下丘脑腹内侧核（VMH）产热和产脂反应的影响。在IBAT温度响应VMH刺激的快速上升被大大抑制在失神经IBAT，而温度反应没有受损，在对侧支配IBAT在相同的动物。同样，[14 C]葡萄糖和[3H]H2O转化为脂肪酸和甘油酯甘油在体内IBAT VMH刺激后，几乎完全抑制交感神经去神经。这些结果清楚地表明，IBAT在VMH刺激反应中的产脂和产热活动的增加是由该组织的交感神经供应介导的。
Effects of unilateral surgical denervation of the interscapular brown adipose tissue (IBAT) on its thermogenic and lipogenic responses to electrical stimulation of the ventromedial hypothalamic (VMH) nucleus were studied in anesthetized rats. The rapid rise in IBAT temperature in response to VMH stimulation was greatly suppressed in the denervated IBAT, whereas the temperature response was not impaired in the contralateral innervated IBAT in the same animals. Similarly, the increased rates of conversion of [14C]glucose and [3H]H2O to fatty acids and glyceride glycerol in vivo in IBAT after VMH stimulation were almost completely inhibited by sympathetic denervation. These results indicate clearly that the increase in lipogenic and thermogenic activities in IBAT in response to VMH stimulation are mediated by the sympathetic nerve supply of this tissue.