Natural Fish Trap-Like Nanocage for Label-Free Capture of Circulating Tumor Cells.
Natural Fish Trap-Like Nanocage for Label-Free Capture of Circulating Tumor Cells.
复制标题
天然鱼陷阱式纳米笼，用于无标记捕获循环肿瘤细胞
DOI：
10.1002/advs.202002259
复制
发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Jia L
中科院分区：
文献类型：
--
作者：
Jiang W;Han L;Yang L;Xu T;He J;Peng R;Liu Z;Zhang C;Yu X;Jia L
在过去的几十年里，纳米材料在捕获循环肿瘤细胞（ctc）方面取得了一些突破。然而，人工制造用于高效CTC捕获的无标签纳米材料仍然是一个挑战。经过数十亿年的进化和自然选择，形成了各种复杂而精确的等级结构。本文报道了一种来自天然菊花花粉的新型鱼饵“纳米笼”结构，并构建了一种具有纳米笼特征的膜，用于无标签捕获CTC和CTC簇。由于纳米笼- CTC丝状伪足匹配、高接触面积和癌细胞与纳米笼之间的强粘附力的协同作用，纳米笼- CTC薄膜有效捕获了92%的罕见癌细胞，具有广谱的癌症类型。此外，这种纳米膜成功地检测了21名不同类型癌症患者（I-IV期）2 mL或4 mL血液中的CTC和CTC簇。这种新颖、丰富、经济的“纳米笼”可能为天然纳米材料在临床CTC捕获和分析中的应用提供新的视角。报道了一种由天然菊花花粉制成的精巧的鱼笼状纳米笼结构。它精确匹配循环肿瘤细胞（CTC）丝状伪足的结构，为广谱癌细胞提供高接触面积和超强粘附力，而不需要任何标记。这种新颖而经济的天然材料显示了来自I-IV期癌症患者的CTC和CTC簇的优越临床捕获性能。
Nanomaterials have achieved several breakthroughs in the capture of circulating tumor cells (CTCs) over the past decades. However, artificial fabrication of label‐free nanomaterials used for high‐efficiency CTC capture is still a challenge. Through billions of years of evolution and natural selection, various complicated and precise hierarchical structures are developed. Here, a novel fish trap‐like “nanocage” structure derived from the natural Chrysanthemum pollen is reported and a nanocage‐featured film for the label‐free capture of CTCs and CTC clusters is constructed. The nanocage‐featured film effectively captures 92% rare cancer cells with a broad spectrum of cancer types, due to the synergistic effect of nanocage‐CTC filopodia matching, high contact area, and strong adhesion force between the cancer cells and the nanocage. Furthermore, the nanocage‐featured film successfully detects CTCs and CTC clusters in 2 or 4 mL blood taken from 21 cancer patients (stages I–IV) suffering from various types of cancers. This novel, abundant, and economical fish trap‐like “nanocage” may provide new perspectives for the application of natural nanomaterials in clinical CTC capture and analysis. An ingenious fish trap‐like nanocage structure derived from natural chrysanthemum pollen is reported. It precisely matches the structure of circulating tumor cell (CTC) filopodia, providing high contact area and ultrastrong adhesion force to broad‐spectrum cancer cells without any labels. This novel and economical natural material shows superior clinical capture performance of CTCs and CTC clusters from patients with stage I–IV cancer.
登录
查看更多内容
影响因子：
11.2
作者：
Attard, Gerhardt;Swermenhuis, Joost F.;de Bono, Johann S.
通讯作者：
de Bono, Johann S.
影响因子：
45.3
作者：
Cristofanilli, M;Hayes, DF;Terstappen, LWMM
通讯作者：
Terstappen, LWMM
影响因子：
3.8
作者：
Gorges TM;Tinhofer I;Drosch M;Röse L;Zollner TM;Krahn T;von Ahsen O
通讯作者：
von Ahsen O
影响因子：
19
作者：
Caballero, David;Palacios, Lucas;Samitier, Josep
通讯作者：
Samitier, Josep
影响因子：
9.9
作者：
Baran, Talat
通讯作者：
Baran, Talat