Renal aquaporins
Renal aquaporins
复制标题
DOI：
10.1038/ki.1996.253
复制
发表时间：
1996-06-01
影响因子：
19.6
通讯作者：
Nielsen, S
中科院分区：
文献类型：
--
作者：
Knepper, MA;Wade, JB;Nielsen, S
水通道蛋白 (AQP) 是新认识的跨膜蛋白家族，具有分子水通道的功能。至少有四种水通道蛋白在肾脏中表达，它们介导水穿过透水性上皮细胞的快速转运，并在尿液浓缩和稀释过程中发挥关键作用。 AQP1 在近曲小管和亨利氏袢降支中以极高水平组成型表达。 AQP2、-3和-4主要在集合管系统中表达。 AQP2 是顶端质膜中的主要水通道，AQP3 和-4 存在于基底外侧质膜中。加压素对集合管水渗透性的短期调节很大程度上是含有 AQP2 的囊泡往返于顶端质膜的调节运输的结果。
Aquaporins (AQPs) are a newly recognized family of transmembrane proteins that function as molecular water channels. At least four aquaporins are expressed in the kidney where they mediate rapid water transport across water-permeable epithelia and play critical roles in urinary concentrating and diluting processes. AQP1 is constitutively expressed at extremely high levels in the proximal tubule and descending limb of Henle's loop. AQP2, -3 and -4 are expressed predominantly in the collecting duct system. AQP2 is the predominant water channel in the apical plasma membrane and AQP3 and -4 are found in the basolateral plasma membrane. Short-term regulation of collecting duct water permeability by vasopressin is largely a consequence of regulated trafficking of AQP2-containing vesicles to and from the apical plasma membrane.