Development of molecularly imprinted polymer films used for detection of profenofos based on a quartz crystal microbalance sensor
Development of molecularly imprinted polymer films used for detection of profenofos based on a quartz crystal microbalance sensor
复制标题
基于石英晶体微天平传感器开发用于检测丙溴磷的分子印迹聚合物薄膜
DOI：
10.1039/c2an16120f
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发表时间：
2012-01-01
期刊：
影响因子：
4.2
通讯作者：
Gao, Zhixian
中科院分区：
文献类型：
--
作者：
Gao, Na;Dong, Jianwei;Gao, Zhixian
研制了一种基于分子印迹超薄薄膜的石英晶体微天平(QCM)传感器，用于检测实际样品中的丙溴磷。比较了物理包埋法(MIP-A)和原位自组装法(MIP-B)制备的薄膜。结果表明，通过原位自组装的方法获得了最佳的传感信号。用11-硫代十一烷酸(MUA)对QCM传感器芯片进行表面处理，形成自组装单分子膜(SAM)，然后采用表面引发自由基聚合法将聚合物膜直接固定在SAM上。在本文中，所有检测实验都是在空气中进行的。反应在溶液中进行，电极用去离子水清洗，用N-2干燥后进行QCM测量。用扫描电子显微镜、交流阻抗和循环伏安法对薄膜进行了表征。丙溴磷在1.0×10~(-8)~1.0×10~(-5)mg·L~(-1)(y=5logx+42.5，R=0.9960)和1.0×10~(-5)~1.0×10~(-3)mg·L~(-1)(y=25.86logx+146，R=0.9959)范围内线性关系良好。MIP-QCM传感器用于自来水中丙溴磷的检测，具有良好的回收率和重现性。
A quartz crystal microbalance (QCM) sensor based on molecularly imprinted ultra-thin films was developed for detecting profenofos in real samples. Films prepared by physical entrapment (MIP-A) and in situ self-assembly (MIP-B) were compared. The results indicated that the best sensing signal was obtained through the in situ self-assembly method. The QCM sensor chip was pretreated with 11-mercaptoundecanoic acid (MUA) to form a self-assembled monolayer (SAM), and then polymer films were immobilized directly on the SAM using surface-initiated radical polymerization. In this paper, all detection experiments were taken in air. The reaction was processed in solution, and the electrode was washed with deionized water and dried with N-2 before QCM measurement. The film was characterized by a scanning electron microscope (SEM), AC impedance and cyclic voltammetry. Analysis of the QCM response in the presence of different concentrations of profenofos showed a good linear correlation during 1.0 x 10(- 8) to 1.0 x 10(-5) mg mL (-1) (y = 5log x + 42.5, R = 0.9960) and 1.0 x 10(-5) to 1.0 x 10(- 3) mg mL(-1) (y = 25.86log x + 146, R 0.9959), respectively. The MIP-QCM sensor was used to detect profenofos in tap water, and showed good recovery and repeatability.