The effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (MPP), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus
The effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (MPP), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus
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DOI：
10.1002/mrd.20520
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发表时间：
2006-08-01
影响因子：
2.5
通讯作者：
Rosenfeld, Cheryl S.
中科院分区：
文献类型：
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作者：
Davis, Angela M.;Ellersieck, Mark R.;Rosenfeld, Cheryl S.
由于雌激素在子宫中具有重要功能，但也可能导致子宫内膜癌，我们试图确定甲基哌啶酮吡唑（MPP）、雷洛昔芬和β -雌二醇对石川和RL-95子宫内膜癌、绵羊腔内内膜（oLE）细胞系的体外作用，以及这些化合物在啮齿动物子宫中的体内作用。与β -雌二醇处理和对照细胞相比，MPP和雷洛昔芬（1 nM）诱导子宫内膜癌和oLE细胞系显著凋亡(P
Since estrogens have vital functions in the uterus but might also contribute to endometrial cancer, we sought to determine the in vitro effects of methyl-piperidino-pyrazole (MPP), raloxifene, and beta-estradiol on Ishikawa and RL-95 endometrial cancer, and ovine luminal endometrial (oLE) cell lines and the in vivo effects of these compounds in the rodent uterus. MPP and raloxifene (1 nM) induced significant apoptosis in the endometrial cancer and oLE cell lines compared to beta-estradiol treated and control cells (P