Relationships between the activity of neurohormonal systems and intracardiac hemodynamics in patients with heart failure: focus on galectin-3
Relationships between the activity of neurohormonal systems and intracardiac hemodynamics in patients with heart failure: focus on galectin-3
复制标题
心力衰竭患者神经激素系统活性与心内血流动力学的关系：关注半乳糖凝集素3
DOI：
10.15829/29/1560-4071-2022-4957
复制
发表时间：
2022
影响因子：
--
通讯作者：
A. V. Tolmacheva
中科院分区：
文献类型：
--
作者：
V. Podzolkov;N. A. Dragomiretsksya;A. Kazadaeva;Yu. G. Beliaev;A. V. Tolmacheva
新的生物标志物的引入需要在具有不同心力衰竭（HF）表型的患者中对其进行详细的研究，作为评估疾病严重程度和预测结果的个性化方法的一部分。为评价射血分数（EF）正常、轻度降低和降低的心力衰竭（HF）患者N末端前利钠肽（NT-proBNP）和半乳糖凝集素-3（galectin-3）的活性，对69例NYHA Ⅱ ~ Ⅳ级HF患者，沿着一般临床检查，采用酶免疫法测定NT-proBNP和血清galectin-3水平。研究中纳入的患者分为3组：EF保留（HFpEF）- 23例患者，EF轻度降低（HFmrEF）- 26例患者，EF降低（HFrEF）- 20例患者。在HF患者中，半乳糖凝集素-3水平不直接依赖于EF，但与NT-proBNP水平相关，如下所示：NT-proBNP三分位组中半乳糖凝集素-3浓度有增加的趋势。相关性分析显示，仅在收缩功能保留的患者中，半乳糖凝集素-3与左心室EF之间存在显著反馈（r=-0.41，p<0.05）。在同一组HFpEF患者中，血清半乳糖凝集素-3指数的最大值为10，5 [6，5; 14，5] ng/ml。神经激素活性分析表明，无论左心室EF如何，HF患者的NT-proBNP和galectin-3单向增加，而在HFpEF患者中观察到galectin-3的最大值。
The introduction of novel biomarkers necessitates their detailed study in patients with different heart failure (HF) phenotypes as part of a personalized approach to assessing the disease severity and predicting outcomes.Aim. To assessthe activity of following neurohormonal systems: N-terminal probrain natriuretic peptide (NT-proBNP) and galectin-3 in HF with preserved, mildly reduced and reduced ejection fraction (EF).Material and methods. In 69 patients with NYHA class II-IV HF, along with a general clinical examination, the level of NT-proBNP and serum galectin-3 was determined by enzyme immunoassay.Results. Patients included in the study were divided into 3 groups: preserved EF (HFpEF) — 23 patients, mildly reduced EF (HFmrEF) — 26 patients, and reduced EF (HFrEF) — 20 patients. In patients with HF, the level of galectin-3 did not directly depend on EF, but was associated with NT-proBNP level as follows: there was a tendency to increase the concentration of galectin-3 in the tertile groups of NT-proBNP. Correlation analysis revealed significant feedback (r=-0,41, p<0,05) between galectin-3 and left ventricular EF only in patients with preserved systolic function. In the same group of HFpEF patients, the maximum values of serum galectin-3 indices were noted, reaching 10,5 [6,5; 14,5] ng/ml.Conclusion. Analysis of neurohormonal activity demonstrated a unidirectional increase in NT-proBNP and galectin-3 in patients with HF, regardless of left ventricular EF, while the maximum values of galetin-3 were observed in patients with HFpEF.