Leinamycin, a new antitumor antibiotic from Streptomyces: producing organism, fermentation and isolation.
Leinamycin, a new antitumor antibiotic from Streptomyces: producing organism, fermentation and isolation.
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DOI：
10.7164/antibiotics.42.1768
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发表时间：
1989-12
期刊：
影响因子：
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通讯作者：
M. Hara;K. Asano;I. Kawamoto;T. Takiguchi;S. Katsumata;K. Takahashi;H. Nakano
中科院分区：
文献类型：
--
作者：
M. Hara;K. Asano;I. Kawamoto;T. Takiguchi;S. Katsumata;K. Takahashi;H. Nakano
莱那霉素（DC 107）是一种新发现的抗肿瘤抗生素，具有1，3-二氧代-1，2-二硫戊环结构.从1985-1988年在日本采集的土壤中分离到5株不同的产生菌，并在分类学上被指定为链霉菌。发酵研究表明：莱那霉素在发酵液中不稳定。化学成分确定的培养基可以设计用于优选生产。链霉菌S-140在添加有Zn 2+和高孔聚合物树脂的培养基上生长，积累了32 μ g/ml的雷那霉素。沿着描述了改进的分离方法，并鉴定了由菌株S-140与莱那霉素共产生的米卡霉素A。
Leinamycin (DC 107) is newly discovered antitumor antibiotic with an unusual 1,3-dioxo-1,2-dithiolane structure. Five different producing strains were isolated from soils collected in Japan during 1985-1988 and were taxonomically assigned as Streptomyces. Fermentation studies indicate: Leinamycin was unstable in culture broth. A chemically defined medium could be designed for a preferable production. Streptomyces sp. S-140 grew on medium supplemented with Zn2+ and high porus polymer resin and accumulated 32 micrograms/ml of leinamycin. Improved isolation methods are described along with identification of mikamycin A co-produced with leinamycin by the strain S-140.