Serum vitamin D concentrations are related to depression in young adult US population: the Third National Health and Nutrition Examination Survey.
Serum vitamin D concentrations are related to depression in young adult US population: the Third National Health and Nutrition Examination Survey.
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DOI：
10.1186/1755-7682-3-29
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发表时间：
2010-11-11
期刊：
影响因子：
--
通讯作者：
Wang YT
中科院分区：
文献类型：
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作者：
Ganji V;Milone C;Cody MM;McCarty F;Wang YT
维生素D受体已被映射到整个大脑，表明维生素D在心身疾病中的作用。以前的流行病学研究结果维生素D状况和抑郁症之间的关系是模棱两可的。此外，有限的信息是可用的维生素D状态与抑郁症的年轻成年美国人口。来自第三次全国健康和营养调查的数据被用来评估7970名年龄在15-39岁之间的非住院美国居民的血清维生素D和抑郁症之间的关联。抑郁症的评估是使用国家精神卫生研究所开发的诊断访谈计划进行的。在多变量logistic回归分析中考虑了几个混杂变量后，我们估计了维生素D缺乏者与维生素D充足者相比患抑郁症的比值比（OR）。妇女、非西班牙裔黑人、生活在贫困线以下的人、不服用补充剂的人、生活在南部和西部地区以及城市地区的人、体重指数较高的人以及目前患有抑郁症的人与他们的同行相比，维生素D缺乏症的患病率较高。血清维生素D ≤ 50 nmol/L的患者目前有抑郁发作的OR显著高于血清维生素D ≥ 75 nmol/L的患者（OR = 1.85; P = 0.021）。在这项基于大规模人群的研究中，维生素D缺乏者患抑郁症的可能性明显高于维生素D充足者。早期诊断和干预至关重要，因为维生素D缺乏症和抑郁症的共存对健康有严重的负面影响。
Vitamin D receptors have been mapped throughout the brain suggesting a role for vitamin D in psychosomatic disorders. Results from previous epidemiological studies on relation between vitamin D status and depression are equivocal. Also, limited information is available relating vitamin D status with depression in young adult US population. Data from the third National Health and Nutrition Examination Survey were used to assess association between serum vitamin D and depression in 7970 non-institutionalized US residents, aged 15-39 y. Assessment of depression was done using the Diagnostic Interview Schedule developed by the National Institute of Mental Health. After accounting for several confounding variables in multivariate logistic regression analysis, we estimated odds ratios (OR) for having depression in vitamin D deficient persons in comparison to vitamin D sufficient persons. Women, non-Hispanic blacks, persons living below poverty, persons who did not consume supplements, persons living in South and West regions and in urban areas, persons with higher BMI, and persons with current depression had higher prevalence of vitamin D deficiency compared to their counterparts. OR for having current depressive episodes in persons with serum vitamin D ≤ 50 nmol/L is significantly higher relative to those with serum vitamin D ≥ 75 nmol/L (OR = 1.85; P = 0.021). In this large population based study, likelihood of having depression in persons with vitamin D deficiency is significantly higher compared to those with vitamin D sufficiency. Early diagnosis and intervention are paramount because coexistence of vitamin D deficiency and depression has serious negative consequences on health.