Amino acids and derivatives, a new treatment of chronic heart failure?
Amino acids and derivatives, a new treatment of chronic heart failure?
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DOI：
10.1007/s10741-014-9436-9
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发表时间：
2015-01-01
影响因子：
4.6
通讯作者：
Lombardi, Carlo
中科院分区：
文献类型：
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作者：
Carubelli, Valentina;Castrini, Anna Isotta;Lombardi, Carlo
氨基酸在多种细胞过程中起着关键作用。心力衰竭（HF）患者的氨基酸可用性降低，对心脏和全身代谢产生有害影响。在衰竭的心脏中已经发现了几种代谢异常，其中许多导致氨基酸需求增加。最近，已经进行了几项临床试验，以证明氨基酸补充剂对HF患者的益处。虽然它们显示出运动耐量的改善，在某些情况下，左心室功能的改善，但它们有许多局限性，即样本量小，患者特征和营养表现的差异，以及缺乏有关结果的数据。此外，最近的数据表明，多种营养方法，包括抗氧化剂，维生素和金属，可能更有效。需要更大规模的试验来确定这种方法在HF中的安全性、有效性和对预后的影响。
Amino acids play a key role in multiple cellular processes. Amino acids availability is reduced in patients with heart failure (HF) with deleterious consequences on cardiac and whole-body metabolism. Several metabolic abnormalities have been identified in the failing heart, and many of them lead to an increased need of amino acids. Recently, several clinical trials have been conducted to demonstrate the benefits of amino acids supplementation in patients with HF. Although they have shown an improvement of exercise tolerance and, in some cases, of left ventricular function, they have many limitations, namely small sample size, differences in patients' characteristics and nutritional supplementations, and lack of data regarding outcomes. Moreover recent data suggest that a multi-nutritional approach, including also antioxidants, vitamins, and metals, may be more effective. Larger trials are needed to ascertain safety, efficacy, and impact on prognosis of such an approach in HF.