Subcutaneous ivermectin as a safe salvage therapy in Strongyloides stercoralis hyperinfection syndrome:: A case report
Subcutaneous ivermectin as a safe salvage therapy in Strongyloides stercoralis hyperinfection syndrome:: A case report
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DOI：
10.4269/ajtmh.2005.73.122
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发表时间：
2005-07-01
影响因子：
3.3
通讯作者：
Cornet, M
中科院分区：
文献类型：
--
作者：
Pacanowski, J;Dos Santos, M;Cornet, M
由于线虫自身感染周期加速而导致的粪类圆线虫过度感染综合征是发生在免疫功能低下宿主中的一种危及生命的感染形式。这种形式中常见的肠梗阻可能会降低生物利用度，从而降低用于治疗粪圆线虫过度感染综合征的口服驱虫药的功效。我们报告了一名感染人类 T 细胞嗜淋巴细胞病毒 I 型并患有粪圆线虫过度感染综合征的患者皮下注射伊维菌素的有效性和安全性，该患者对伊维菌素和阿苯达唑的口服组合无反应。
Strongyloides stercoralis hyperinfection syndrome due to the acceleration of the autoinfective cycle of the nematode is a life-threatening form of the infection occurring in immunocompromised hosts. Intestinal ileus, which is commonly encountered in this form, may reduce the bioavailability and thus the efficacy of oral anthelminthic drugs used in the treatment of the S. stercoralis hyperinfection syndrome. We report the efficacy and safety of subcutaneous administration of ivermectin in a patient infected with human T cell lymphotropic virus type I with S. stercoralis hyperinfection syndrome who was unresponsive to an oral combination of ivermectin and albendazole.