Relationship between choroidal blood flow velocity and choroidal thickness during systemic corticosteroid therapy for Vogt-Koyanagi-Harada disease
Relationship between choroidal blood flow velocity and choroidal thickness during systemic corticosteroid therapy for Vogt-Koyanagi-Harada disease
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DOI：
10.1007/s00417-014-2927-5
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发表时间：
2015-04-01
影响因子：
2.7
通讯作者：
Ishida, Susumu
中科院分区：
文献类型：
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作者：
Hirooka, Kiriko;Saito, Wataru;Ishida, Susumu
为探讨Vogt-Koyanagi-Harada（VKH）病患者全身皮质类固醇治疗期间脉络膜形态学与循环血流动力学之间的关系，本回顾性病例系列包括9例VKH病患者（2男7女;平均年龄40.8岁）的18只眼，这些患者接受了全身皮质类固醇治疗。分别于治疗前、治疗后1周、1个月、3个月行激光散斑血流图（LSFG）和增强深度成像光学相干断层扫描（EDI-OCT）检查。比较各期黄斑部平均模糊率（MBR）和中心脉络膜厚度（CCT）的平均值，治疗开始后各期MBR的平均变化率均较治疗前显著增加，浆液性视网膜脱离（SRD）消退（P均= 0.0002）。与治疗前值相比，治疗开始后所有检查的CCT均显着下降（全部P = 0.0002）。3个月随访期间MBR和CCT的变化显著相关（R =-0.5913，P = 0.0097）。治疗前最佳矫正视力与0 ~ 3个月的MBR变化率显著相关（R = 0.5944，P = 0.0093），而与CCT无相关性，提示循环障碍和脉络膜增厚与VKH的发病机制有关。LSFG可作为评价VKH疾病脉络膜炎活动性的指标，EDI-OCT也是如此。
To investigate the relationship between circulation hemodynamics and morphology in the choroid during systemic corticosteroid therapy for patients with Vogt-Koyanagi-Harada (VKH) disease.This retrospective case series includes 18 eyes of nine patients with VKH disease (two men and seven women; average age, 40.8 years) who received systemic corticosteroid therapy. Laser speckle flowgraphy (LSFG) and enhanced-depth imaging optical coherence tomography (EDI-OCT) were performed before treatment and at 1 week and 1 and 3 months after treatment. The average values of the mean blur rate (MBR) at the macula and the central choroidal thickness (CCT) were compared at each stage.The changing rates of the average MBR significantly increased at all examinations after the start of treatment compared with the pre-treatment value with resolution of serous retinal detachment (SRD) (P = 0.0002 for all). The CCT decreased significantly at all examinations after the start of treatment compared with the pre-treatment value (P = 0.0002 for all). Changes in MBR and CCT during the 3-month follow-up period correlated significantly (R = -0.5913, P = 0.0097). The best-corrected visual acuity at pre-treatment correlated significantly with the changing rate of the MBR from 0 to 3 months (R = 0.5944, P = 0.0093) but not with CCT.Our data suggest that circulatory disturbances and increased thickness of the choroid relate to the pathogenesis of VKH disease with link mutually. LSFG is useful as an index for evaluating the choroiditis activity of VKH disease as well as EDI-OCT.