Control of the in vivo Biodistribution of Hybrid Nanoparticles with Different Poly(ethylene glycol) Coatings
Control of the in vivo Biodistribution of Hybrid Nanoparticles with Different Poly(ethylene glycol) Coatings
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DOI：
10.1002/smll.200900563
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发表时间：
2009-11-16
期刊：
影响因子：
13.3
通讯作者：
Tillement, Olivier
中科院分区：
文献类型：
--
作者：
Faure, Anne-Charlotte;Dufort, Sandrine;Tillement, Olivier
含有氧化钆核的荧光纳米颗粒非常有吸引力，因为它们能够将成像（荧光成像、磁共振成像）和治疗（X射线治疗和中子捕获治疗）技术联合收割机结合。将这些多功能颗粒用于体内应用需要准确控制其生物分布。这些颗粒的postfunctionalization由四种不同的聚（乙二醇）衍生物，不同的链长和端基，发挥了很大的影响，对潜在的纳米粒子和他们的生物分布后，静脉注射到HEK-β 3-荷瘤小鼠。这项研究表明，通过体内荧光成像监测的PEG化纳米颗粒的行为取决于PEG链的链长和端基。
Fluorescent nanoparticles containing a gadolinium oxide core are very attractive because they are able to combine both imaging (fluorescence imaging, magnetic resonance imaging) and therapy (X-ray therapy and neutron-capture therapy) techniques. The exploitation of these multifunctional particles for in vivo applications requires accurate control of their biodistribution. The postfunctionalization of these particles by four different poly(ethylene glycol) derivatives, which differ by chain length and end group, exerts a great influence on the potential of the nanoparticles and on their biodistribution after intravenous injection to HEK-beta 3-tumor-bearing mice. This study reveals that the behavior of PEGylated nanoparticles, which was monitored by in vivo fluorescence imaging, depends on both the chain length and the end group of the PEG chain.