Genetic Diversity among Staphylococcus aureus Isolates Showing Oxacillin and/or Cefoxitin Resistance Not Linked to the Presence of mec Genes
Genetic Diversity among Staphylococcus aureus Isolates Showing Oxacillin and/or Cefoxitin Resistance Not Linked to the Presence of mec Genes
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DOI：
10.1128/aac.00091-18
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发表时间：
2018-07-01
影响因子：
4.9
通讯作者：
Denis, O.
中科院分区：
文献类型：
--
作者：
Argudin, M. Angeles;Roisin, S.;Denis, O.
从比利时医院收集的缺乏mec基因的耐甲氧西林金黄色葡萄球菌分离株（n = 32）的特征是它们的β -内酰胺酶产生和pbp基因、pbp4启动子以及与青霉素结合蛋白4过量产生（gdpP和yjbH）有关的基因的突变。12株菌株为β -内酰胺酶高产菌株（BHPs），而12株非bhp菌株可能产生不完全GdpP蛋白。多数分离株pbp基因出现核苷酸错义突变。少数分离株也显示pbp4启动子突变。
Methicillin-resistant Staphylococcus aureus isolates lacking mec genes (n = 32), collected from Belgian hospitals, were characterized for their beta-lactamase production and the presence of mutations in pbp genes, the pbp4 promoter, and genes involved in penicillin-binding protein 4 overproduction (gdpP and yjbH). Twelve isolates were beta-lactamase hyperproducers (BHPs), while 12 non-BHP isolates might produce an incomplete GdpP protein. Most isolates showed nucleotide missense mutations in pbp genes. A few isolates also showed mutations in the pbp4 promoter.