Antiulcer effect of naringin on gastric lesions induced by ethanol in rats.
Antiulcer effect of naringin on gastric lesions induced by ethanol in rats.
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DOI：
10.1159/000139228
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发表时间：
1994-07
期刊：
影响因子：
3.1
通讯作者：
M. J. Martin;E. Marhuenda;C. Pérez-Guerrero;J. Franco
中科院分区：
文献类型：
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作者：
M. J. Martin;E. Marhuenda;C. Pérez-Guerrero;J. Franco
本研究旨在确定柚皮苷对无水乙醇引起的胃粘膜损伤的保护作用以及内源性柚皮苷的参与。无水乙醇灌胃前60 min给予最高剂量的柚皮苷（400 mg/kg）是最有效的抗溃疡治疗方法。皮下注射吲哚美辛（10毫克/公斤）的柚苷（400毫克/公斤）治疗的动物部分抑制胃保护，但前列腺素E2测定没有显示任何增加前列腺素水平。胃粘液和总蛋白含量无明显变化。柚苷处理的大鼠表现出显着增加氨基己糖水平，但这种增加是在动物与吲哚美辛预处理。这些结果表明，柚苷对大鼠乙醇损伤具有“细胞保护”作用，但这种性质似乎是由非前列腺素依赖性机制介导的。
This study was designed to determine the gastroprotective properties of naringin on and the involvement of endogenous prostaglandins in mucosal injury produced by absolute ethanol. Oral pretreatment with the highest dose of naringin (400 mg/kg), 60 min before absolute ethanol was the most effective antiulcer treatment. Subcutaneous administration of indomethacin (10 mg/kg) to the animals treated with naringin (400 mg/kg) partially inhibited gastric protection, but the prostaglandin E2 determination did not show any increase in prostanoid levels. The contents of gastric mucus and total proteins were not significantly modified. Naringin-treated rats showed a marked increase in hexosamine levels, but this increase was less in animals pretreated with indomethacin. These results show that naringin has a 'cytoprotective' effect against ethanol injury in the rat, but this property appears to be mediated by non-prostaglandin-dependent mechanisms.