Relationship between plasma cortisol levels, withdrawal symptoms and craving in abstinent and treated heroin addicts
Relationship between plasma cortisol levels, withdrawal symptoms and craving in abstinent and treated heroin addicts
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DOI：
10.1300/j069v25n02_02
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发表时间：
2006-01-01
影响因子：
2.3
通讯作者：
Lucchini, Alfio
中科院分区：
文献类型：
--
作者：
Nava, Felice;Caldiroli, Emanuela;Lucchini, Alfio
用美沙酮或丁丙诺啡治疗海洛因成瘾者10个月，使血浆皮质醇水平正常化，并控制了戒断症状和渴望。在治疗过程中，血浆皮质醇水平和渴望的时间过程中没有严格的相关性：海洛因的渴望是在12比3 months.The结果表明，皮质醇增多症，戒断症状和海洛因使用之间的相关性，并假设一个更复杂的角色，渴望和它的组件在吸毒行为。阿片类药物依赖的药物治疗的主要目标应该是下丘脑-垂体-肾上腺皮质（HPA）轴的正常化，而不是在控制的渴望。
Twelve-month treatment of heroin addicts with methadone or buprenorphine normalized plasma cortisol levels, and controlled withdrawal symptoms as well as craving. During treatment, the time course of plasma cortisol levels and craving was not strictly correlated: heroin craving was more elevated at 12 than at 3 months.The results suggest a correlation between hypercortisolism, withdrawal symptoms and heroin use and suppose a more complex role for craving and its components in drug-taking behaviour. The main goal of the pharmacological treatment of opioid-dependence should be addressed at the normalization of hypothalamic-pituitary-adrenocortical (HPA) axis more than at the control of craving.