Signals and noise in an inhibitory interneuron diverge to control activity in nearby retinal ganglion cells
Signals and noise in an inhibitory interneuron diverge to control activity in nearby retinal ganglion cells
复制标题
DOI：
10.1038/nn2045
复制
发表时间：
2008-03-01
影响因子：
25
通讯作者：
Rieke, Fred
中科院分区：
文献类型：
--
作者：
Murphy, Gabe J.;Rieke, Fred
关于感觉刺激的信息由神经活动的时空模式表示。然而，中枢神经系统的复杂性经常掩盖了这些活动模式背后的信号和噪声的来源和性质。我们通过检查小鼠视网膜神经节细胞（RGC）中相关活动的机制来最大限度地减少这种限制，在这种条件下，光诱发的反应穿过一个特定的电路，视杆双极通路。该电路中的信号和噪声产生相关的突触输入到相邻的开和关RGC。光强度的时间调制并没有改变噪声在输入到附近的RGC的相关程度，在个别RGC的动作电位生成在很大程度上是不敏感的动态和静态光刺激所产生的网络噪声的差异。总之，这些功能使共享电路中的噪声能够在各种条件下减少相邻On和Off RGC中同时产生的动作电位。
Information about sensory stimuli is represented by spatiotemporal patterns of neural activity. The complexity of the central nervous system, however, frequently obscures the origin and properties of signals and noise that underlie these activity patterns. We minimized this constraint by examining mechanisms governing correlated activity in mouse retinal ganglion cells (RGCs) under conditions in which light-evoked responses traverse a specific circuit, the rod bipolar pathway. Signals and noise in this circuit produced correlated synaptic input to neighboring On and Off RGCs. Temporal modulation of light intensity did not alter the degree to which noise in the input to nearby RGCs was correlated, and action potential generation in individual RGCs was largely insensitive to differences in network noise generated by dynamic and static light stimuli. Together, these features enable noise in shared circuitry to diminish simultaneous action potential generation in neighboring On and Off RGCs under a variety of conditions.