Magnetic resonance imaging and clinical relationships in multiple sclerosis.
Magnetic resonance imaging and clinical relationships in multiple sclerosis.
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多发性硬化症的磁共振成像和临床关系。
DOI：
10.1016/s0025-6196(12)62439-2
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发表时间：
1987
影响因子：
8.9
通讯作者：
Rodriguez,M
中科院分区：
文献类型：
--
作者：
Stewart,JM;Houser,OW;BakerJr,HL;O'Brien,PC;Rodriguez,M
对109例疑似脱髓鞘疾病患者(56例临床多发性硬化症，53例非多发性硬化症)进行了磁共振成像(MRI)检查。在临床多发性硬化症患者中，43例(77%)在MRI上发现脑白质多灶性病变；43例患者中有12例也有融合的脑室周围信号。9名(17%)无临床多发性硬化症的患者也有类似的发现。56例多发性硬化患者中，35例同时进行了CT和MRI检查。在这组中，80%的MRI扫描显示与MS相容的多发性脱髓鞘病变，而CT扫描的这一比例为29%。如果在多发性硬化症发作后1个月内获得CT扫描结果，其“阳性”率比晚些时候更高。相比之下，在近期病情恶化的患者中，MRI的敏感性或MRI检测到的病变数量并没有增加。临床多发性硬化症患者的MRI“阳性”率高于任何单一的诱发反应研究。在统计学分析中，MRI的敏感性和病变的数量都与MS的持续时间有关。侧脑室周围的汇合信号模式与MS的持续时间和患者的残疾有关。
Magnetic resonance imaging (MRI) was done in 109 patients with suspected demyelinating disease (56 with clinical multiple sclerosis [MS] and 53 without). Of those with clinical MS, 43 (77%) had multifocal lesions of the white matter detected on MRI; 12 of the 43 also had confluent periventricular signaling. Nine patients (17%) without clinical MS had similar findings. Of the 56 patients with MS, 35 underwent both computed tomography (Ct) and MRI. In this group, 80% of MRI scans showed multiple demyelinating lesions compatible with MS, as compared with 29% of the CT scans. A CT scan was “positive” more often if obtained within 1 month after an attack of MS than later. In contrast, the sensitivity of MRI or the number of lesions detected by MRI did not increase in patients with recent exacerbations. MRI was “positive” in patients with clinical MS more often than was any single evoked response study. In statistical analyses, both the sensitivity of MRI and the number of lesions were associated with the duration of MS. A pattern of confluent periventricular signaling around the lateral ventricle was associated with greater duration of MS and patient disability.