Biochemical differences between products of the Adh locus in Drosophila.
Biochemical differences between products of the Adh locus in Drosophila.
复制标题
果蝇中 Adh 基因座产物之间的生化差异。
作者：
J. McDonald;S. M. Anderson;M. Santos
对在黑腹果蝇自然群体中发现的主要醇脱氢酶 (E.C.1.1.1.1.) 同种异型酶变体的分子特性进行了分析。我们的结果表明：（1）ADH-S酶的米氏常数普遍低于ADH-F的米氏常数； (2) ADH-S和ADH-F酶对辅因子和底物表现出相反的相互作用； (3) ADH 水平较高与 Adh-fast 基因型相关。讨论了这些发现的可能的适应性意义。
An analysis of the molecular properties of the major alcohol dehydrogenase (E.C.1.1.1.1.) allozyme variants found segregating in natural populations of D. melanogaster is presented. Our results indicate: (1) ADH-S enzyme has generally lower Michaelis-Menten constants than those of ADH-F; (2) ADH-S and ADH-F enzymes display opposite interactions for both co-factor and substrate; and (3) higher levels of ADH are associated with the Adh-fast genotype. The possible adaptive significance of these findings is discussed.