Evaluation of 13C-phenylalanine and 13C-tyrosine breath tests for the measurement of hepatocyte functional capacity in patients with liver cirrhosis
Evaluation of 13C-phenylalanine and 13C-tyrosine breath tests for the measurement of hepatocyte functional capacity in patients with liver cirrhosis
复制标题
DOI：
10.1248/cpb.49.1507
复制
发表时间：
2001-12-01
影响因子：
1.7
通讯作者：
Kajiwara, M
中科院分区：
文献类型：
--
作者：
Ishii, T;Furube, M;Kajiwara, M
肝病与血浆芳香族氨基酸苯丙氨酸和酪氨酸浓度异常升高有关。肝脏是芳香族氨基酸代谢的主要部位，特别是苯丙氨酸羟化为酪氨酸，并进一步降解酪氨酸。本文探讨了L-[1-C-13]苯丙氨酸呼气试验(C-13-PheBT)和L-[1-C-13]酪氨酸呼气试验(C-13-TyrBT)对肝硬变患者肝损害的诊断价值。首先，比较了L-[1-C-13]苯丙氨酸和L-[1-C-13]酪氨酸给药后(CO_2)-C-13排泄的时程。两种呼气试验的峰值时间(以分钟为单位)均为20min，但C-13-TyrBT的峰值高于C-13-PheBT。接下来，将C-13-PheBT和C-13-TyrBT的参数与生化肝功能检测值进行比较。这些参数与传统上被认为是肝细胞功能储备的几个肝脏血液测试值有很好的相关性。因此，C-13-PheBT和C-13-TyrBT可能有助于评估肝功能障碍的程度和进展。
Liver disease is associated with an abnormal elevation of the plasma concentrations of the aromatic amino acids phenylalanine and tyrosine. The liver is the main site of aromatic amino acid metabolism, particularly the hydroxylation of phenylalanine to tyrosine and further tyrosine degradation. In the present study, we have examined the usefulness of the L-[1-C-13]phenylalanine breath test (C-13-PheBT) and L-[1-C-13]tyrosine breath test (C-13-TyrBT) for the detection of hepatic damage in patients with liver cirrhosis. First, the time courses of (CO2)-C-13 excretion after the administration of L-[1-C-13]phenylalanine and L-[1-C-13] tyrosine were compared. The peak times (the time expressed in minutes at which (CO2)-C-13 excretion was maximal) were 20 min in both breath tests, but C-13-TyrBT gave a higher peak than C-13-PheBT. Next, the parameters of C-13-PheBT and C-13-TyrBT were compared with biochemical liver function test values. These parameters were well correlated with several liver blood test values conventionally regarded as measures of hepatocyte functional reserve. Therefore, C-13-PheBT and C-13-TyrBT may be useful to assess the degree and progression of hepatic dysfunction.