Vasculogenic female sexual dysfunction: The hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency
Vasculogenic female sexual dysfunction: The hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency
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DOI：
10.1038/sj.ijir.3900258
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发表时间：
1997-03-01
影响因子：
2.6
通讯作者：
Azadzoi, KM
中科院分区：
文献类型：
--
作者：
Park, K;Goldstein, I;Azadzoi, KM
目的：器质性女性性功能障碍可能与胃下阴道/阴蒂动脉床血管源性损伤有关。目的是建立阴道充血功能不全和阴蒂勃起功能不全的动物模型。方法：采用盆腔神经刺激阴道膨大和阴蒂勃起的新西兰白兔对照组（正常饮食，n=8）和动脉粥样硬化组（主动脉-髂动脉球囊损伤，0.5%胆固醇饮食，n=7）。16周后，记录两组患者新的血流动力学变量，包括阴道壁和阴蒂血流量、阴道壁和阴蒂海膜内压、阴道长度、阴道腔压、血液中胆固醇和甘油三酯水平、主动脉-髂血管造影、阴道壁和阴蒂勃起组织组织学。结果：在盆腔神经刺激下的阴道血流动力学变化方面，动脉粥样硬化组（9.3 +/- 3.7、4.8 +/- 3.8、67.3 +/- 8.3）血流量（ml/min/100 gm组织）、壁压（mmHg）和长度变化（mm）分别明显低于对照组（13.9 +/- 4.5、5.5 +/- 2.6、74.1 +/- 10.0）。阴蒂勃起组织的组织学检查显示海绵体动脉粥样硬化改变，阴道和阴蒂弥漫性纤维化。动脉粥样硬化动物的主动脉-髂血管造影显示弥漫性中度至重度动脉粥样硬化闭塞。结论：阴道充血和阴蒂勃起依赖于血流量的增加。动脉粥样硬化与阴道充血功能不全和阴蒂勃起功能不全有关。
Objective: Organic female sexual dysfunction may be related in part to vasculogenic impairment of the hypogastric-vaginal/clitoral arterial bed. The aim was to develop an animal model of vaginal engorgement insufficiency and clitoral erectile insufficiency.Methods: pelvic nerve stimulated vaginal engorgement and clitoral erection were achieved in control (normal diet, n=8) and atherosclerotic (balloon injury of aorto-iliac arteries and 0.5% cholesterol diet, n=7) New Zealand White female rabbits. After 16 weeks, novel hemodynamic variables including vaginal wall and clitoral blood now, vaginal wall and clitoral intracavernosal pressure, vaginal length, vaginal luminal pressure, blood levels of cholesterol and triglycerides, aorto-iliac angiography and vaginal wall and clitoral erectile tissue histology were recorded in the two groups.Results: Concerning pelvic nerve stimulated vaginal hemodynamic changes, there was significantly less increase in blood now (ml/min/100 gm tissue), wall pressure (mmHg) and length changes (mm) in atherosclerotic (9.3 +/- 3.7, 4.8 +/- 3.8, 67.3 +/- 8.3) compared to control (13.9 +/- 4.5, 5.5 +/- 2.6, 74.1 +/- 10.0) animals respectively. Histologic examination of clitoral erectile tissue demonstrated cavernosal artery atherosclerotic changes and diffuse vaginal and clitoral fibrosis. Aorto-iliac angiography in atherosclerotic animals revealed diffuse moderate to severe atherosclerotic occlusion.Conclusions: Vaginal engorgement and clitoral erection depend on increased blood inflow. Atherosclerosis is associated with vaginal engorgement insufficiency and clitoral erectile insufficiency.