A Hybrid Oscillatory Interference/Continuous Attractor Network Model of Grid Cell Firing
A Hybrid Oscillatory Interference/Continuous Attractor Network Model of Grid Cell Firing
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DOI：
10.1523/jneurosci.4017-13.2014
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发表时间：
2014-04-02
影响因子：
5.3
通讯作者：
Burgess, Neil
中科院分区：
文献类型：
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作者：
Bush, Daniel;Burgess, Neil
在啮齿动物内侧内嗅皮层的网格细胞表现出非常有规律的空间放电模式，镶嵌所有的环境访问的动物。已经提出了两种理论机制，可以产生这种空间周期性的活动模式：振荡干扰和连续吸引子动力学。虽然已经引用了各种证据来支持每一个，但这两种机制的某些方面是互补的，这表明组合模型可能最好地解释实验数据。振荡干涉模型提出，网格图案由线性干涉图案或“周期带”形成，其中速度控制振荡器将自运动集成到沿着沿着优选方向的编码位移。然而，它也允许使用网格单元之间的对称经常性连接，以提供相对稳定性和连续的吸引子动态。在这里，我们提出了这种类型的混合模型的模拟，表明它产生的细胞内膜电位分布，密切匹配在体内观察到的，解决了几个批评，旨在纯振荡干扰和连续吸引子模型，并提供可测试的预测，为未来的实证研究。
Grid cells in the rodent medial entorhinal cortex exhibit remarkably regular spatial firing patterns that tessellate all environments visited by the animal. Two theoretical mechanisms that could generate this spatially periodic activity pattern have been proposed: oscillatory interference and continuous attractor dynamics. Although a variety of evidence has been cited in support of each, some aspects of the two mechanisms are complementary, suggesting that a combined model may best account for experimental data. The oscillatory interference model proposes that the grid pattern is formed from linear interference patterns or "periodic bands" in which velocity-controlled oscillators integrate self-motion to code displacement along preferred directions. However, it also allows the use of symmetric recurrent connectivity between grid cells to provide relative stability and continuous attractor dynamics. Here, we present simulations of this type of hybrid model, demonstrate that it generates intracellular membrane potential profiles that closely match those observed in vivo, addresses several criticisms aimed at pure oscillatory interference and continuous attractor models, and provides testable predictions for future empirical studies.